Zebrafish as a model system for studying reproductive diseases

W Zha, W Hu, C Ge, J Chen, Z Cao - Frontiers in Cell and …, 2024 - frontiersin.org
Reproductive system diseases have become a major health challenge facing humans, so
extensive investigations are needed to understand their complex pathogenesis and …

Intersection of the orphan G protein-coupled receptor, GPR19, with the aging process

S Maudsley, D Walter, C Schrauwen… - International journal of …, 2022 - mdpi.com
G protein-coupled receptors (GPCRs) represent one of the most functionally diverse classes
of transmembrane proteins. GPCRs and their associated signaling systems have been …

Establishment and application of a zebrafish model of Werner syndrome identifies sapanisertib as a potential antiaging drug

J Ma, Y Chen, J Song, Q Ruan, L Li, L Luo - Proceedings of the National …, 2025 - pnas.org
Aging is a complex process that affects multiple organs, and the discovery of a
pharmacological approach to ameliorate aging is considered the Holy Grail of medicine …

Identification of candidate genomic regions for egg yolk moisture content based on a genome-wide association study

R Zhang, F Yao, X Cheng, M Yang, Z Ning - BMC genomics, 2023 - Springer
Background Eggs represent important sources of protein and are widely loved by
consumers. Egg yolk taste is an important index for egg selection, and the moisture content …

[HTML][HTML] RecQ dysfunction contributes to social and depressive-like behavior and affects aldolase activity in mice

Y Hou, JH Park, X Dan, X Chu, B Yang, M Hussain… - Neurobiology of …, 2023 - Elsevier
RecQ helicase family proteins play vital roles in maintaining genome stability, including DNA
replication, recombination, and DNA repair. In human cells, there are five RecQ helicases …

Unraveling DNA Repair Processes In Vivo: Insights from Zebrafish Studies

U Shin, Y Lee - International Journal of Molecular Sciences, 2023 - mdpi.com
The critical role of the DNA repair system in preserving the health and survival of living
organisms is widely recognized as dysfunction within this system can result in a broad range …

HELQ deficiency impairs the induction of primordial germ cell‐like cells

C Wan, Y Huang, X Xue, G Chang, M Wang… - FEBS Open …, 2024 - Wiley Online Library
Helicase POLQ‐like (HELQ) is a DNA helicase essential for the maintenance of genome
stability. A recent study identified two HELQ missense mutations in some cases of infertile …

The cGAS-STING pathway is an in vivo modifier of genomic instability syndromes

M Bergman, U Goshtchevsky, T Atlan, G Astre… - bioRxiv, 2024 - biorxiv.org
Mutations in genes involved in DNA damage repair (DDR) often lead to premature aging
syndromes. While recent evidence suggests that inflammation, alongside mutation …

The role of BLM and RecQL4 helicases in defining the response of glioma cells to chemotherapeutics: PhD thesis

K Wojnicki - 2023 - rcin.org.pl
Malignant gliomas are primary tumours of the central nervous system. They remain one of
the hardest to treat brain tumours due to their invasive phenotype, the immunosuppressive …