Solid-state nuclear magnetic resonance (ssNMR) spectroscopy enables the structural
characterization of a diverse array of biological assemblies that include amyloid fibrils, non …

Cholesterol in the circulation is mostly transported in an esterified form as a component of
lipoproteins. The majority of these cholesteryl esters are produced in nascent, discoidal high …

The N-terminal fragment of apolipoprotein AI (apoA-I), comprising residues 1–83, contains
three segments prone to aggregation: residues 14–22, 53–58, and 67–72. We previously …

Solid-state NMR methods incorporating dynamics-based spectral editing have a remarkable
versatility for resolving and separately characterizing co-existing solid and liquid phases or …

Protein-protein interactions play important roles for a variety of cell functions, often involving
metal ions; in fact, metal-ion binding mediates and regulates the activity of a wide range of …

Chronic systemic inflammation is associated with an increased risk of cardiovascular
disease in an environment of low low-density lipoprotein (LDL) and low total cholesterol and …

The N-terminal (1–83) fragment of the major constituent of plasma high-density lipoprotein,
apolipoprotein AI (apoA-I), strongly tends to form amyloid fibrils, leading to systemic …

We previously demonstrated that apolipoprotein AI (apoA-I), the major protein component of
high-density lipoprotein (HDL), is an important target for myeloperoxidase (MPO)-catalyzed …

Hyperhomocysteinemia (hHcy) represents a strong risk factor for atherosclerosis-associated
diseases, like stroke, dementia or Alzheimer's disease. A methionine (Met)-rich diet leads to …

Amyloid deposits of apolipoprotein AI (apoA-I) and inflammation are common in
atherosclerotic arteries. In this study, we investigated the interplay between oxidation of …