Targeting carbonic anhydrases for the management of hypoxic metastatic tumors
CT Supuran - Expert Opinion on Therapeutic Patents, 2023 - Taylor & Francis
Introduction Several isoforms of the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1)
are connected with tumorigenesis. Hypoxic tumors overexpress CA IX and XII as a …
are connected with tumorigenesis. Hypoxic tumors overexpress CA IX and XII as a …
[HTML][HTML] Tumor associated carbonic anhydrase inhibitors: rational approaches, design strategies, structure activity relationship and mechanistic insights
The emergence of tumor-associated human carbonic anhydrases (hCA) as promising
therapeutic targets has urged rigorous research into the development of potent and selective …
therapeutic targets has urged rigorous research into the development of potent and selective …
Identification of thienopyrimidine derivatives tethered with sulfonamide and other moieties as carbonic anhydrase inhibitors: design, synthesis and anti-proliferative …
S Higazy, N Samir, A El-Khouly, S Giovannuzzi… - Bioorganic …, 2024 - Elsevier
Eighteen novel compounds harboring the privileged thienopyrimidine scaffold (5a-q, and
6a), were designed based on molecular hybridization strategy. These compounds were …
6a), were designed based on molecular hybridization strategy. These compounds were …
[HTML][HTML] Exploring heterocyclic scaffolds in carbonic anhydrase inhibition: a decade of structural and therapeutic insights
N Naeem, A Sadiq, GA Othman, HM Yassin… - RSC …, 2024 - pubs.rsc.org
Heterocyclic compounds represent a prominent class of molecules with diverse
pharmacological activities. Among their therapeutic applications, they have gained …
pharmacological activities. Among their therapeutic applications, they have gained …
Synthesis and investigation of selective human carbonic anhydrase IX, XII inhibitors using coumarins bearing a sulfonamide or biotin moiety
The role of carbonic anhydrases isoforms (CAs) IX and XII in the pathogenesis and
progression of many types of solid tumors is well known. In this context, selective CA …
progression of many types of solid tumors is well known. In this context, selective CA …
Chemistry of heterocycles as carbonic anhydrase inhibitors: A pathway to novel research in medicinal chemistry review
Nowadays, the scientific community has focused on dealing with different kinds of diseases
by exploring the chemistry of various heterocycles as novel drugs. In this connection …
by exploring the chemistry of various heterocycles as novel drugs. In this connection …
Synthesis and In Silico Study of New Acetazolamide Derivatives Incorporating a 1, 2, 4-Triazole Moiety as Potential Carbonic Anhydrase Inhibitors and Anti-cancer …
IA Bachay, NH Naser - Tropical Journal of Natural Product …, 2024 - search.ebscohost.com
Abstract A significant number of 1, 2, 4-triazole derivatives are known to possess numerous
pharmacological properties. The present study aims to synthesize new acetazolamide …
pharmacological properties. The present study aims to synthesize new acetazolamide …