Amyloid protein fibrillation is responsible for variety of neurological disorders and thus
inhibition of fibrillation is a potential therapeutic strategy for these diseases. Recent study …

The synthesis of a water/plasma soluble, noncytotoxic,“clicked” sugar-derivative of curcumin
with amplified bioefficacy in modulating amyloid-β and tau peptide aggregation is presented …

To precisely manipulate the intracellular delivery of pleiotropic curcumin, this work reports
two types of acid-responsive polymer–curcumin conjugates with different structures. One or …

Curcumin has anti-proliferative and pro-apototic properties against a variety of cancer cells
in vitro. Unfortunately, the water-insolubility and instability leads to its low bioavailability in …

Abnormal aggregation of β-amyloid (Aβ) peptides into toxic aggregates has been identified
as a key event in Alzheimer's disease (AD). Inhibition of this process has thus emerged as a …

The azide− alkyne cycloaddition “click” reaction was used to covalently bond high loadings
of polymers and monosaccharides to the surface of an ordered mesoporous silica. The …

Dendrimers have been shown to be capable of interfering in vitro with the formation of the
amyloid fibrillar structures typically related to the onset and development of the so-called …

摘要采用活性基团拼接法将含氟苯甲醛与酮反应, 合成了5 个含氟单羰基姜黄素类似物,
结构经IR, 1 H NMR 及ESI-MS 确认. 对所合成的化合物进行了抗肿瘤活性测试(MTT 法) …

摘要近年来, 天然产物姜黄素因其显著的抗肿瘤等多种生物活性引起广泛关注.
然而姜黄素水溶性差, 化学结构不稳定, 生物利用度低, 限制了其在临床上的进一步应用 …

There are many reports proved great potential effects of curcumin in various diseases.
Curcumin exhibits antioxidant, anti inflammation, antimicrobial and anticarcinogenic …