Mechanisms of glucose absorption in the small intestine in health and metabolic diseases and their role in appetite regulation
LV Gromova, SO Fetissov, AA Gruzdkov - Nutrients, 2021 - mdpi.com
The worldwide prevalence of metabolic diseases such as obesity, metabolic syndrome and
type 2 diabetes shows an upward trend in recent decades. A characteristic feature of these …
type 2 diabetes shows an upward trend in recent decades. A characteristic feature of these …
Dopamine signaling in reward-related behaviors
JH Baik - Frontiers in neural circuits, 2013 - frontiersin.org
Dopamine (DA) regulates emotional and motivational behavior through the mesolimbic
dopaminergic pathway. Changes in DA mesolimbic neurotransmission have been found to …
dopaminergic pathway. Changes in DA mesolimbic neurotransmission have been found to …
Relation of reward from food intake and anticipated food intake to obesity: a functional magnetic resonance imaging study.
The authors tested the hypothesis that obese individuals experience greater reward from
food consumption (consummatory food reward) and anticipated consumption (anticipatory …
food consumption (consummatory food reward) and anticipated consumption (anticipatory …
Relation Between Obesity and Blunted Striatal Response to Food Is Moderated by TaqIA A1 Allele
The dorsal striatum plays a role in consummatory food reward, and striatal dopamine
receptors are reduced in obese individuals, relative to lean individuals, which suggests that …
receptors are reduced in obese individuals, relative to lean individuals, which suggests that …
Weight gain is associated with reduced striatal response to palatable food
Consistent with the theory that individuals with hypofunctioning reward circuitry overeat to
compensate for a reward deficit, obese versus lean humans have fewer striatal D2 receptors …
compensate for a reward deficit, obese versus lean humans have fewer striatal D2 receptors …
Hormonal and neural mechanisms of food reward, eating behaviour and obesity
With rising rates of obesity, research continues to explore the contributions of homeostatic
and hedonic mechanisms related to eating behaviour. In this Review, we synthesize the …
and hedonic mechanisms related to eating behaviour. In this Review, we synthesize the …
Youth at risk for obesity show greater activation of striatal and somatosensory regions to food
Obese humans, compared with normal-weight humans, have less striatal D2 receptors and
striatal response to food intake; weaker striatal response to food predicts weight gain for …
striatal response to food intake; weaker striatal response to food predicts weight gain for …
The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight
BM King - Physiology & behavior, 2006 - Elsevier
Early researchers found that lesions of the ventromedial hypothalamus (VMH) resulted in
hyperphagia and obesity in a variety of species including humans, which led them to …
hyperphagia and obesity in a variety of species including humans, which led them to …
Antipsychotic drugs: from receptor-binding profiles to metabolic side effects
Background: Antipsychotic-induced metabolic side effects are major concerns in
psychopharmacology and clinical psychiatry. Their pathogenetic mechanisms are still not …
psychopharmacology and clinical psychiatry. Their pathogenetic mechanisms are still not …
Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism
A Kern, R Albarran-Zeckler, HE Walsh, RG Smith - Neuron, 2012 - cell.com
We identified subsets of neurons in the brain that coexpress the dopamine receptor subtype-
2 (DRD2) and the ghrelin receptor (GHSR1a). Combination of FRET confocal microscopy …
2 (DRD2) and the ghrelin receptor (GHSR1a). Combination of FRET confocal microscopy …