Neuroblastoma is a leading cause of cancer-related death in children. Accumulated data
suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage …

Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer. NEPC arises
de novo only rarely; the disease predominantly develops from adenocarcinoma in response …

Acquired resistance to tyrosine kinase inhibitors (TKI), such as osimertinib used to treat
EGFR-mutant lung adenocarcinomas, limits long-term efficacy and is frequently caused by …

Childhood high-risk neuroblastomas with MYCN gene amplification are difficult to treat
effectively. This has focused attention on tumor-specific gene dependencies that underlie …

Summary ARID1A, an SWI/SNF chromatin-remodeling gene, is commonly mutated in cancer
and hypothesized to be tumor suppressive. In some hepatocellular carcinoma patients …

Background Aberrant changes in epigenetic mechanisms such as histone modifications play
an important role in cancer progression. PRMT1 which triggers asymmetric dimethylation of …

Background SMARCA4, the essential ATPase subunit of SWI/SNF chromatin remodeling
complex, regulates transcription through the control of chromatin structure and is …

Mammalian SWI/SNF (BAF) chromatin remodeling complexes orchestrate a diverse set of
chromatin alterations which impact transcriptional output. Recent whole-exome sequencing …

Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes
resistant and requires more potent therapies. One mechanism of resistance observed in …

Small cell lung cancers (SCLCs) are composed of heterogeneous subtypes marked by
lineage-specific transcription factors, including ASCL1, NEUROD1, and POU2F3. POU2F3 …