Integrated approaches using different in vitro methods in combination with bioinformatics
can (i) increase the success rate and speed of drug development;(ii) improve the accuracy of …

Plasmodium vivax is the major species of malaria parasite outside Africa. It is especially
problematic in that the infection can relapse in the absence of mosquitoes by activation of …

Various factors, including the phylogenetic distance between laboratory animals and
humans, the discrepancy between current in vitro systems and the human body, and the …

Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard
assessment. Since the interpretation of animal data and their extrapolation to man is …

The possibility to generate dopaminergic (DA) neurons from pluripotent stem cells
represents an unlimited source of material for tissue engineering and cell therapy for …

Glioblastoma is the most common malignant primary central nervous system tumor and one
of the most debilitating cancers. The prognosis of patients with glioblastoma remains poor …

The gastrointestinal (GI) tract is an important target organ for the toxicity of xenobiotics. The
toxic effects of xenobiotics on this complex, heterogeneous structure have been difficult to …

Developmental neurotoxicity (DNT) is a serious concern for environmental chemicals, as
well as for food and drug constituents. Animal-based DNT models have relatively low …

The rising prevalence of progressive neurodegenerative diseases coupled with increasing
longevity poses an economic burden at individual and societal levels. There is currently no …

Human brain organoids provide a remarkable opportunity to model prenatal human brain
biology in vitro by recapitulating features of in utero molecular, cellular and systems biology …