Immune modulation by mesenchymal stem cells

W Jiang, J Xu - Cell proliferation, 2020 - Wiley Online Library
Mesenchymal stem cells (MSCs) can be derived from various adult tissues with multipotent
and self‐renewal abilities. The characteristics of presenting no major ethical concerns …

Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy

XL Fan, Y Zhang, X Li, QL Fu - Cellular and molecular life sciences, 2020 - Springer
Mesenchymal stem cells (MSCs) have been extensively investigated for the treatment of
various diseases. The therapeutic potential of MSCs is attributed to complex cellular and …

Immunomodulatory mechanisms of mesenchymal stem cells and their potential clinical applications

Y Huang, Q Wu, PKH Tam - International Journal of Molecular Sciences, 2022 - mdpi.com
Mesenchymal stem cells (MSCs) are multipotent stem cells with the capacity of self-renewal,
homing, and low immunogenicity. These distinct biological characteristics have already …

[HTML][HTML] Mesenchymal stem cell-based therapy of osteoarthritis: Current knowledge and future perspectives

CR Harrell, BS Markovic, C Fellabaum… - Biomedicine & …, 2019 - Elsevier
Osteoarthritis (OA) is a chronic, prevalent, debilitating joint disease characterized by
progressive cartilage degradation, subchondral bone remodeling, bone marrow lesions …

Mesenchymal stem cell therapy for the treatment of inflammatory diseases: challenges, opportunities, and future perspectives

S Regmi, S Pathak, JO Kim, CS Yong… - European journal of cell …, 2019 - Elsevier
Mesenchymal stem cells (MSCs) are promising alternative agents for the treatment of
inflammatory disorders due to their immunomodulatory functions, and several clinical trials …

Neuroinflammation and scarring after spinal cord injury: therapeutic roles of MSCs on inflammation and glial scar

QM Pang, SY Chen, QJ Xu, SP Fu, YC Yang… - Frontiers in …, 2021 - frontiersin.org
Transected axons are unable to regenerate after spinal cord injury (SCI). Glial scar is
thought to be responsible for this failure. Regulating the formation of glial scar post-SCI may …

Multipotent mesenchymal stromal cells and the innate immune system

K Le Blanc, D Mougiakakos - Nature Reviews Immunology, 2012 - nature.com
Multipotent mesenchymal stromal cells (MSCs) have unique immunoregulatory and
regenerative properties that make them an attractive tool for the cellular treatment of …

Mechanisms of mesenchymal stromal cell immunomodulation

K English - Immunology and cell biology, 2013 - Wiley Online Library
Multipotent mesenchymal stromal cells (MSCs) have generated considerable interest in the
fields of regenerative medicine, cell therapy and immune modulation. Over the past 5 years …

[HTML][HTML] Mesenchymal stem cells: emerging mechanisms of immunomodulation and therapy

JD Glenn, KA Whartenby - World journal of stem cells, 2014 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) are a pleiotropic population of cells that are self-renewing
and capable of differentiating into canonical cells of the mesenchyme, including adipocytes …

The regulation of the Treg/Th17 balance by mesenchymal stem cells in human systemic lupus erythematosus

D Wang, S Huang, X Yuan, J Liang, R Xu… - Cellular & Molecular …, 2017 - nature.com
Background and objective: Umbilical cord (UC)-derived mesenchymal stem cells (MSCs)
have shown immunoregulation of various immune cells. The aim of this study was to …