Estradiol, either from peripheral or central origin, activates multiple molecular
neuroprotective and neuroreparative responses that, being mediated by estrogen receptors …

The nervous system is a target and a source of steroids. Neuroactive steroids are steroids
that target neurons and glial cells. They include hormonal steroids originated in the …

Ischemia-reperfusion injury (I/R injury) is a common feature of ischemic stroke which occurs
when blood supply is restored after a period of ischemia. Although stroke is an important …

Patients surviving traumatic brain injury (TBI) face numerous neurological and
neuropsychological problems significantly affecting their quality of life. Extensive studies …

There are sexual differences in the onset, prevalence, and outcome of numerous
neurological diseases. Thus, in Alzheimer's disease, multiple sclerosis, and major …

Oxidative stress, resulting from accumulation of reactive oxygen species, plays a critical role
in astroglial cell death occurring in diverse neuropathological conditions. Numerous studies …

Obesity is considered one of the greatest risk to human health and is associated with several
factors including genetic components, diet, and physical inactivity. Recently, the relationship …

Neuroglobin is expressed in vertebrate brain and belongs to a branch of the globin family
that diverged early in evolution. Sequence conservation and presence in nervous cells of …

High concentrations of palmitic acid in plasma increase both the inflammation associated
with obesity and the susceptibility to develop a neurodegenerative event. In the brain, the …

Estradiol exerts neuroprotective actions that are mediated by the regulation of a variety of
signaling pathways and homeostatic molecules. Among these is neuroglobin, which is …