Our understanding of the functions of ceramide signaling has advanced tremendously over
the past decade. In this review, we focus on the roles and regulation of neutral …

Among the family of phospholipases A 2 (PLA 2 s) are the Ca 2+-independent PLA 2 s (iPLA
2 s) and they are designated group VI iPLA 2 s. In relation to secretory and cytosolic PLA 2 s …

Sphingolipids play an important role in the development of diabetes, both type 1 and type 2
diabetes, as well as in the development of both micro-and macro-vascular complications …

Calcium-independent phospholipase A2β (iPLA2β) regulates important physiological
processes including inflammation, calcium homeostasis and apoptosis. It is genetically …

Calcium-independent phospholipase A 2 β (iPLA 2 β), a member of the phospholipase A2
(PLA2s) superfamily, is encoded by the PLA2G6 gene. Mutations in the PLA2G6 gene have …

Nutrient sensing mechanisms of carbohydrates, amino acids and lipids operate distinct
pathways that are essential for the adaptation to varying metabolic conditions. The role of …

The continuous detection of enzyme activities and their application in medical diagnostics is
one of the challenges in the translational sciences. Proteinases represent one of the largest …

Macrophages are important in innate and adaptive immunity. Macrophage participation in
inflammation or tissue repair is directed by various extracellular signals and mediated by …

Cadmium (Cd) is a ubiquitous heavy metal with neurotoxicity. Our previous study reported
that Cd could inhibit the proliferation of mouse neural stem cells (mNSCs). However, the …

Aims: Berberine (BBR) improves beta-cell function in Type 2 diabetes (T2D) because of its
anti-apoptotic activity, and our laboratory developed a new preparation named Huang-Gui …