Macrophage compartmentalization in the brain and cerebrospinal fluid system

DAD Munro, K Movahedi, J Priller - Science immunology, 2022 - science.org
Macrophages reside within the diverse anatomical compartments of the central nervous
system (CNS). Within each compartment, these phagocytes are exposed to unique …

[HTML][HTML] The choroid plexus synergizes with immune cells during neuroinflammation

H Xu, P Lotfy, S Gelb, A Pragana, C Hehnly, LIJ Byer… - Cell, 2024 - cell.com
The choroid plexus (ChP) is a vital brain barrier and source of cerebrospinal fluid (CSF).
Here, we use longitudinal two-photon imaging in awake mice and single-cell transcriptomics …

CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation

J Yan, K Kothur, S Mohammad, J Chung, S Patel… - …, 2023 - thelancet.com
Background Defining the presence of acute and chronic brain inflammation remains a
challenge to clinicians due to the heterogeneity of clinical presentations and aetiologies …

The diverse cellular responses of the choroid plexus during infection of the central nervous system

AN Lauer, T Tenenbaum… - American Journal of …, 2018 - journals.physiology.org
The choroid plexus (CP) is responsible for the production of a large amount of the
cerebrospinal fluid (CSF). As a highly vascularized structure, the CP also presents a …

T cell derived HIV-1 is present in the CSF in the face of suppressive antiretroviral therapy

G Lustig, S Cele, F Karim, A Derache, A Ngoepe… - PLoS …, 2021 - journals.plos.org
HIV cerebrospinal fluid (CSF) escape, where HIV is suppressed in blood but detectable in
CSF, occurs when HIV persists in the CNS despite antiretroviral therapy (ART). To determine …

Characterization and diagnosis spectrum of patients with cerebrospinal fluid pleocytosis

S Dyckhoff-Shen, JP Bewersdorf, NC Teske, S Völk… - Infection, 2024 - Springer
Purpose There is an overlap in the cerebrospinal fluid (CSF) characteristics of patients
presenting with different etiologies of CSF pleocytosis. Here, we characterized patients with …

Immune-mediated myelopathies

M Levy - CONTINUUM: Lifelong Learning in Neurology, 2024 - journals.lww.com
Immune-Mediated Myelopathies : CONTINUUM: Lifelong Learning in Neurology Account
Register Activate Subscription Help Subscribe American Academy of Neurology Login Journal …

Utility of chemokines CCL2, CXCL8, 10 and 13 and interleukin 6 in the pediatric cohort for the recognition of neuroinflammation and in the context of traditional …

Z Liba, H Nohejlova, V Capek, P Krsek, A Sediva… - PLoS …, 2019 - journals.plos.org
Background The recognition of active inflammation in the central nervous system (CNS) in
the absence of infectious agents is challenging. The present study aimed to determine the …

A collaboration between immune cells and the choroid plexus epithelium in brain inflammation

H Xu, P Lotfy, S Gelb, A Pragana, C Hehnly, FB Shipley… - bioRxiv, 2023 - biorxiv.org
The choroid plexus (ChP) is a vital brain barrier and source of cerebrospinal fluid (CSF).
Here, we use chronic two-photon imaging in awake mice and single-cell transcriptomics to …

Seizures in adults with suspected central nervous system infection

SE Olie, IE Van Zeggeren, L Ter Horst… - BMC neurology, 2022 - Springer
Background Seizures can be part of the clinical presentation of central nervous system
(CNS) infections. We describe patients suspected of a neurological infection who present …