Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections
and cancers in animal models and humans. Tex cells are characterized by progressive loss …

The success of antiretroviral therapy has led some people to now ask whether the end of
AIDS is possible. For patients who are motivated to take therapy and who have access to …

HIV prevalence is increasing worldwide because people on antiretroviral therapy are living
longer, although new infections decreased from 3· 3 million in 2002, to 2· 3 million in 2012 …

Quantitative lymphocyte alterations are frequent in patients with cancer, and strongly impact
prognosis and survival. The development of cancers in immunosuppressed patients has …

Combination antiretroviral therapy for HIV infection improves immune function and
eliminates the risk of AIDS-related complications but does not restore full health. HIV …

Abstract Interleukin-2 (IL-2) signals influence various lymphocyte subsets during
differentiation, immune responses and homeostasis. As discussed in this Review …

COVID-19 is a distinctive infection characterized by elevated inter-human transmission and
presenting from absence of symptoms to severe cytokine storm that can lead to dismal …

Interleukin-2 (IL-2) exerts crucial functions during immune homeostasis via its effects on
regulatory T (Treg) cells, and the optimizing and fine-tuning of effector lymphocyte …

Background Dysfunction of regulatory T (Treg) cells has been detected in diverse
inflammatory disorders, including chronic graft-versus-host disease (GVHD). Interleukin-2 is …

Context New trial data and drug regimens that have become available in the last 2 years
warrant an update to guidelines for antiretroviral therapy (ART) in human immunodeficiency …