Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies

NC Noronha, A Mizukami, C Caliári-Oliveira… - Stem cell research & …, 2019 - Springer
Multipotent mesenchymal stromal cells (MSC) have been widely explored for cell-based
therapy of immune-mediated, inflammatory, and degenerative diseases, due to their …

Biological functions of mesenchymal stem cells and clinical implications

A Naji, M Eitoku, B Favier, F Deschaseaux… - Cellular and Molecular …, 2019 - Springer
Mesenchymal stem cells (MSCs) are isolated from multiple biological tissues—adult bone
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …

Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine

FJ Vizoso, N Eiro, S Cid, J Schneider… - International journal of …, 2017 - mdpi.com
Earlier research primarily attributed the effects of mesenchymal stem cell (MSC) therapies to
their capacity for local engrafting and differentiating into multiple tissue types. However …

Preconditioning influences mesenchymal stem cell properties in vitro and in vivo

C Hu, L Li - Journal of cellular and molecular medicine, 2018 - Wiley Online Library
Various diseases and toxic factors easily impair cellular and organic functions in mammals.
Organ transplantation is used to rescue organ function, but is limited by scarce resources …

Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects

M Li, Y Jiang, Q Hou, Y Zhao, L Zhong, X Fu - Stem cell research & …, 2022 - Springer
Mesenchymal stem cell (MSC)-based therapy has been considered as a promising
approach targeting a variety of intractable diseases due to remarkable multiple effect of …

Preconditioning and Engineering Strategies for Improving the Efficacy of Mesenchymal Stem Cell‐Derived Exosomes in Cell‐Free Therapy

S Chen, F Sun, H Qian, W Xu, J Jiang - Stem cells international, 2022 - Wiley Online Library
Mesenchymal stem cells (MSCs) have been widely applied to regenerative medicine owing
to their multiple differentiation, self‐renewal, and immunomodulatory abilities. Exosomes are …

Relevance of oxygen concentration in stem cell culture for regenerative medicine

C Mas-Bargues, J Sanz-Ros… - International journal of …, 2019 - mdpi.com
The key hallmark of stem cells is their ability to self-renew while keeping a differentiation
potential. Intrinsic and extrinsic cell factors may contribute to a decline in these stem cell …

[HTML][HTML] Determination of protein carbonyls in plasma, cell extracts, tissue homogenates, isolated proteins: Focus on sample preparation and derivatization conditions

D Weber, MJ Davies, T Grune - Redox biology, 2015 - Elsevier
Protein oxidation is involved in regulatory physiological events as well as in damage to
tissues and is thought to play a key role in the pathophysiology of diseases and in the aging …

Metformin facilitates mesenchymal stem cell-derived extracellular nanovesicles release and optimizes therapeutic efficacy in intervertebral disc degeneration

Z Liao, S Li, S Lu, H Liu, G Li, L Ma, R Luo, W Ke… - Biomaterials, 2021 - Elsevier
Extracellular vesicles (EVs) are extracellular nanovesicles that deliver diverse cargoes to the
cell and participate in cell communication. Mesenchymal stem cell (MSCs)-derived EVs are …

[HTML][HTML] Mesenchymal stem cells homing to improve bone healing

W Lin, L Xu, S Zwingenberger, E Gibon… - Journal of orthopaedic …, 2017 - Elsevier
Cell therapy continues to attract growing interest as a promising approach to treat a variety
of diseases. Mesenchymal stem cells (MSCs) have been one of the most intensely studied …