The β Subunit of Voltage-Gated Ca2+ Channels
Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …
contraction, neuronal communication, hormone release, cell division, and gene …
[HTML][HTML] Structure and function of the β subunit of voltage-gated Ca2+ channels
The voltage-gated Ca2+ channel β subunit (Cavβ) is a cytosolic auxiliary subunit that plays
an essential role in regulating the surface expression and gating properties of high-voltage …
an essential role in regulating the surface expression and gating properties of high-voltage …
Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation
F Findeisen, DL Minor, Jr - Channels, 2010 - Taylor & Francis
Voltage-gated calcium channels (CaVs) are large, transmembrane multiprotein complexes
that couple membrane depolarization to cellular calcium entry. These channels are central …
that couple membrane depolarization to cellular calcium entry. These channels are central …
Mechanism of auxiliary β‐subunit‐mediated membrane targeting of L‐type (CaV1.2) channels
K Fang, HM Colecraft - The Journal of physiology, 2011 - Wiley Online Library
Non‐technical summary Voltage‐dependent L‐type calcium (CaV1. 2) channels are critical
gateways for Ca2+ entry into excitable cells such as heart myocytes and neurons. This Ca2+ …
gateways for Ca2+ entry into excitable cells such as heart myocytes and neurons. This Ca2+ …
β‐adrenergic‐mediated dynamic augmentation of sarcolemmal CaV1.2 clustering and co‐operativity in ventricular myocytes
DW Ito, KI Hannigan, D Ghosh, B Xu… - The Journal of …, 2019 - Wiley Online Library
Key points Prevailing dogma holds that activation of the β‐adrenergic receptor/cAMP/protein
kinase A signalling pathway leads to enhanced L‐type CaV1. 2 channel activity, resulting in …
kinase A signalling pathway leads to enhanced L‐type CaV1. 2 channel activity, resulting in …
G protein inhibition of CaV2 calcium channels
KPM Currie - Channels, 2010 - Taylor & Francis
Voltage-gated Ca2+ channels translate the electrical inputs of excitable cells into
biochemical outputs by controlling influx of the ubiquitous second messenger Ca2+. As such …
biochemical outputs by controlling influx of the ubiquitous second messenger Ca2+. As such …
Targeting the CaVα–CaVβ interaction yields an antagonist of the N-type CaV2. 2 channel with broad antinociceptive efficacy
Inhibition of voltage-gated calcium (CaV) channels is a potential therapy for many
neurological diseases including chronic pain. Neuronal CaV1/CaV2 channels are …
neurological diseases including chronic pain. Neuronal CaV1/CaV2 channels are …
Modulation of Cav1. 3 Ca2+ channel gating by Rab3 interacting molecule
M Gebhart, G Juhasz-Vedres, A Zuccotti… - Molecular and Cellular …, 2010 - Elsevier
Neurotransmitter release and spontaneous action potentials during cochlear inner hair cell
(IHC) development depend on the activity of Cav1. 3 voltage-gated L-type Ca2+ channels …
(IHC) development depend on the activity of Cav1. 3 voltage-gated L-type Ca2+ channels …
Multiple C‐terminal tail Ca2+/CaMs regulate CaV1.2 function but do not mediate channel dimerization
EY Kim, CH Rumpf, F Van Petegem, RJ Arant… - The EMBO …, 2010 - embopress.org
Interactions between voltage‐gated calcium channels (CaVs) and calmodulin (CaM)
modulate CaV function. In this study, we report the structure of a Ca2+/CaM CaV1. 2 C …
modulate CaV function. In this study, we report the structure of a Ca2+/CaM CaV1. 2 C …
Molecular endpoints of Ca2+/calmodulin- and voltage-dependent inactivation of Cav1.3 channels
Ca2+/calmodulin-and voltage-dependent inactivation (CDI and VDI) comprise vital
prototypes of Ca2+ channel modulation, rich with biological consequences. Although the …
prototypes of Ca2+ channel modulation, rich with biological consequences. Although the …