The role of normal transcription and RNA processing in maintaining genome integrity is
becoming increasingly appreciated in organisms ranging from bacteria to humans. Several …

Abstract Histone H3 lysine 9 (H3K9) methylation is a conserved modification that generally
represses transcription. In Caenorhabditis elegans it is enriched on silent tissue-specific …

Centromeres play a crucial role in DNA segregation by mediating the cohesion and
separation of sister chromatids during cell division. Centromere dysfunction, breakage or …

We implicated the X-chromosome THOC2 gene, which encodes the largest subunit of the
highly-conserved TREX (Tr anscription-Ex port) complex, in a clinically complex …

The integrity and proper expression of genomes are safeguarded by DNA and RNA
surveillance pathways. While many RNA surveillance factors have additional functions in the …

The brown mussel Perna perna is a valuable fishing resource, primarily in tropical and
subtropical coastal regions. Because of their filter-feeding habits, mussels are directly …

Animals constantly encounter environmental and physiological stressors that threaten
survival and fertility. Somatic stress responses and germ cell arrest/repair mechanisms are …

Neurodegenerative diseases with tau pathology, or tauopathies, include Alzheimer's
disease and related dementia disorders. Previous work has shown that loss of the poly (A) …

THO/TREX (transcription/export) is a conserved eukaryotic complex that plays a crucial role
in gene expression and prevents DNA damage during mitosis and meiosis. In mammals …

The evolutionarily conserved multiprotein complex THO/TREX is required for pre‐mRNA
processing, mRNA export and the maintenance of genome stability. In this study, we …