The four natural DNA bases (A, T, G and C) associate in base pairs (A= T and G≡ C),
allowing the attached DNA strands to assemble into the canonical double helix of DNA (or …

Tyrosine-type site-specific recombinases (T-SSRs) have opened new avenues for the
predictable modification of genomes as they enable precise genome editing in heterologous …

The use of Cre recombinase to carry out conditional mutagenesis of transgenes and insert
DNA cassettes into eukaryotic chromosomes is widespread (1–9). Indeed, a PubMed search …

Cre recombinase is a phage-derived enzyme that has found utility for precise manipulation
of DNA sequences. Cre recognizes and recombines pairs of loxP sequences characterized …

DNA has been a key target for cancer therapy, with a range of compounds able to bind and
either impair its processing or induce damage. Targeting DNA with small molecules in a truly …

Damaging DNA is a current and efficient strategy to fight against cancer cell proliferation.
Numerous mechanisms exist to counteract DNA damage, collectively referred to as the DNA …

Holliday 4-way junctions are key to important biological DNA processes (insertion,
recombination, and repair) and are dynamic structures that adopt either open or closed …

Inhibition of tyrosine kinases (such as the epidermal growth factor receptor, EGFR, and/or
Abelson leukemia virus protein kinase, ABL) represents a major advancement in the …

The λ site‐specific recombination pathway has enjoyed the sequential attentions of
geneticists, biochemists, and structural biologists for more than 50 years. It has proven to be …

Tyrosine family site‐specific recombinases (YRs), named after the active site tyrosine
nucleophile they utilize for DNA strand breakage, are widely distributed among prokaryotes …