[HTML][HTML] Repurposing anticancer drugs for the management of COVID-19

K El Bairi, D Trapani, A Petrillo, C Le Page… - European Journal of …, 2020 - Elsevier
Since its outbreak in the last December, coronavirus disease 2019 (COVID-19) caused by
SARS-CoV-2 has rapidly spread worldwide at a pandemic proportion and thus is regarded …

Sphingolipids in viral infection

J Schneider-Schaulies… - Biological chemistry, 2015 - degruyter.com
Viruses exploit membranes and their components such as sphingolipids in all steps of their
life cycle including attachment and membrane fusion, intracellular transport, replication …

Recent advances in the development of sphingosine kinase inhibitors

MR Pitman, M Costabile, SM Pitson - Cellular signalling, 2016 - Elsevier
Abstract Sphingosine kinase (SK) 1 and 2 are lipid kinases that catalyse the formation of
sphingosine 1-phosphate (S1P), a potent signalling molecule with a wide array of cellular …

SARS-CoV-2 infection: a role for S1P/S1P receptor signaling in the nervous system?

E Meacci, M Garcia-Gil, F Pierucci - International Journal of Molecular …, 2020 - mdpi.com
The recent coronavirus disease (COVID-19) is still spreading worldwide. The severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), the virus responsible for COVID-19 …

Ceramide Suppresses Influenza A Virus Replication In Vitro

N Soudani, R Hage-Sleiman, W Karam… - Journal of …, 2019 - Am Soc Microbiol
Annual influenza outbreaks are associated with significant morbidity and mortality worldwide
despite the availability of seasonal vaccines. Influenza pathogenesis depends on the …

Transient inhibition of sphingosine kinases confers protection to influenza A virus infected mice

C Xia, YJ Seo, CJ Studstill, M Vijayan, JJ Wolf, B Hahm - Antiviral research, 2018 - Elsevier
Influenza continues to pose a threat to public health by causing illness and mortality in
humans. Discovering host factors that regulate influenza virus propagation is vital for the …

[HTML][HTML] Sphingosine kinase 2 restricts T cell immunopathology but permits viral persistence

CJ Studstill, CJ Pritzl, YJ Seo, DY Kim… - The Journal of …, 2020 - Am Soc Clin Investig
Chronic viral infections are often established by the exploitation of immune-regulatory
mechanisms that result in nonfunctional T cell responses. Viruses that establish persistent …

Potential drug development and therapeutic approaches for clinical intervention in COVID-19

J Dowarah, BN Marak, UCS Yadav, VP Singh - Bioorganic Chemistry, 2021 - Elsevier
While the vaccination is now available to many countries and will slowly dissipate to others,
effective therapeutics for COVID-19 is still illusive. The SARS-CoV-2 pandemic has posed …

Sphingosine kinase 2 is a chikungunya virus host factor co-localized with the viral replication complex

SP Reid, SR Tritsch, K Kota, CY Chiang… - Emerging microbes & …, 2015 - Taylor & Francis
Chikungunya virus (CHIKV) is a re-emerging alphavirus which causes severe and
prolonged arthralgic febrile illness. The recent global spread of the virus and lack of …

Enzymatic independent role of sphingosine kinase 2 in regulating the expression of type I interferon during influenza A virus infection

M Xu, S Xia, M Wang, X Liu, X Li, W Chen… - PLoS …, 2022 - journals.plos.org
Influenza virus has the ability to circumvent host innate immune system through regulating
certain host factors for its effective propagation. However, the detailed mechanism is still not …