Selenium in cancer prevention: a review of the evidence and mechanism of action

MP Rayman - Proceedings of the Nutrition Society, 2005 - cambridge.org
Se is an unusual trace element in having its own codon in mRNA that specifies its insertion
into selenoproteins as selenocysteine (SeCys), by means of a mechanism requiring a large …

Selenium: its role as antioxidant in human health

U Tinggi - Environmental health and preventive medicine, 2008 - Springer
Selenium (Se) is an essential trace element, and its low status in humans has been linked to
increased risk of various diseases, such as cancer and heart disease. In recent years, Se …

Role of diet in prostate cancer development and progression

JM Chan, PH Gann, EL Giovannucci - Journal of Clinical Oncology, 2005 - ascopubs.org
Increasing evidence supports the important role of nutrition in cancer prevention, including
prevention of prostate cancer. In this review, we summarize data for some of the most …

Dietary cancer and prevention using antimutagens

LR Ferguson, M Philpott, N Karunasinghe - Toxicology, 2004 - Elsevier
Many of the cancers common in the Western world, including colon, prostate and breast
cancers, are thought to relate to dietary habits. Of the known risk factors, many will act …

Selenium level and cognitive function in rural elderly Chinese

S Gao, Y Jin, KS Hall, C Liang… - American journal of …, 2007 - academic.oup.com
Selenium is a trace element associated with antioxidant activity and is considered to be a
protective agent against free radicals through enhanced enzyme activity. Studies on …

Selenium and its' role in the maintenance of genomic stability

LR Ferguson, N Karunasinghe, S Zhu… - … research/fundamental and …, 2012 - Elsevier
Selenium (Se) is an essential micronutrient for humans, acting as a component of the
unusual amino acids, selenocysteine (Se-Cys) and selenomethionine (Se-Met). Where Se …

Genetic factors in chronic inflammation: single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn's disease in a New …

LR Ferguson, DY Han, AG Fraser, C Huebner… - Mutation Research …, 2010 - Elsevier
The Signal Transducers and Activators of Transcription (STAT)–Janus kinase (JAK) pathway
controls signal transduction between cell surface receptors and the nucleus. Two members …

Adaptive dysfunction of selenoproteins from the perspective of the triage theory: why modest selenium deficiency may increase risk of diseases of aging

JC McCann, BN Ames - The FASEB Journal, 2011 - Wiley Online Library
The triage theory proposes that modest deficiency of any vitamin or mineral (V/M) could
increase age‐related diseases. V/M‐dependent proteins required for short‐term survival …

Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention?

S Bera, VD Rosa, W Rachidi, AM Diamond - Mutagenesis, 2013 - academic.oup.com
The trace element selenium is an essential micronutrient that has received considerable
attention for its potential use in the prevention of cancer. In spite of this interest, the …

High potential for selenium biofortification of lentils (Lens culinaris L.)

D Thavarajah, J Ruszkowski… - Journal of Agricultural …, 2008 - ACS Publications
Beneficial forms of selenium (Se) and their impact on human health are a global topic of
interest in public health. We are studying the genetic potential for Se biofortification of pulse …