Rolling circle amplification (RCA) is an efficient enzymatic isothermal reaction that using
circular probe as a template to generate long tandem single-stranded DNA or RNA products …

Extracellular vesicles (EVs) play an important role in many physiological processes. Thus,
EV analysis has a great value for the understanding of mechanisms underlying disease …

Tumor-derived extracellular vesicle (tEV) biomarkers can reflect cancer cell phenotypes and
have great potential for cancer diagnosis and treatment. However, tEVs display high …

Circle-to-circle amplification (C2CA) is a specific and precise cascade nucleic acid
amplification method consisting of more than one round of padlock probe ligation and rolling …

MicroRNAs (miRNAs) detection with high specificity and sensitivity received abundant
attention because miRNAs have been reported to play a vital role in pathological …

Small extracellular vesicles (sEVs), often referred to as exosomes, are potential biomarkers
for noninvasive cancer diagnosis. However, because of their phenotype heterogeneity …

CD63, a member of transmembrane-4-superfamily of tetraspanin proteins and a highly N-
glycosylated type III lysosomal membrane protein, is known to regulate malignancy of …

Exosomes are emerging as one of the most promising biomarkers for early disease
diagnosis and prognosis. The significant challenges facing the available methods include …

Extracellular vesicles (EVs) are emerging as promising biomarkers for cancer diagnosis and
therapy. Recognizing low-abundance EVs from clinical samples in an easy-to-operate way …

In the past decade, the study of extracellular vesicles (EVs), especially exosomes (50–150
nm) have attracted growing interest in numerous areas of cancer and tissue regeneration …