Aggregation-induced emission photosensitizer-based photodynamic therapy in cancer: from chemical to clinical

Z Meng, H Xue, T Wang, B Chen, X Dong… - Journal of …, 2022 - Springer
Cancer remains a serious threat to human health owing to the lack of effective treatments.
Photodynamic therapy (PDT) has emerged as a promising non-invasive cancer treatment …

Recent progress of metal‐based nanomaterials with anti‐tumor biological effects for enhanced cancer therapy

H Lei, Z Pei, C Jiang, L Cheng - Exploration, 2023 - Wiley Online Library
Metal‐based nanomaterials have attracted broad attention recently due to their unique
biological physical and chemical properties after entering tumor cells, namely biological …

Self-driven nanoprodrug platform with enhanced ferroptosis for synergistic photothermal-IDO immunotherapy

P Huang, Y Yang, W Wang, Z Li, N Gao, H Chen… - Biomaterials, 2023 - Elsevier
Insufficient immune stimulation and stubborn immune resistance are the critical factors
limiting tumor immunotherapy. Here, we report a multifunctional nanoprodrug platform with …

Metformin modified chitosan as a multi-functional adjuvant to enhance cisplatin-based tumor chemotherapy efficacy

Z Zhou, Y Liu, X Jiang, C Zheng, W Luo, X Xiang… - International Journal of …, 2023 - Elsevier
Recently, it was newly revealed that the DNA damage induced by cis‑platinum (Cis-Pt)
mediated chemotherapy was significantly impaired by the highly expressed programmed …

A metal–phenolic nanocoordinator launches radiotherapeutic cancer pyroptosis through an epigenetic mechanism

G Wang, B Li, H Tian, L Xie, J Yan… - Advanced Functional …, 2023 - Wiley Online Library
Radiotherapy, although clinically effective in immunoactivation, still cannot radio‐
functionalize tumor as a potent immunogenetic center. Given that newly found pyroptosis …

A type I AIE photosensitiser-loaded biomimetic nanosystem allowing precise depletion of cancer stem cells and prevention of cancer recurrence after radiotherapy

S Ning, T Zhang, M Lyu, JWY Lam, D Zhu, Q Huang… - Biomaterials, 2023 - Elsevier
Radioresistance of Cancer stem cell (CSC) is an important cause of tumor recurrence after
radiotherapy (RT). Herein, we designed a type I aggregation-induced emission (AIE) …

Killing three birds with one stone: Multi-stage metabolic regulation mediated by clinically usable berberine liposome to overcome photodynamic immunotherapy …

C Zheng, W Luo, Y Liu, J Chen, H Deng, Z Zhou… - Chemical Engineering …, 2023 - Elsevier
Nowadays, photodynamic therapy (PDT) has become a novel effect modality for cancer
therapy. But, facing the extremely hypoxic tumor microenvironment, the efficacy of PDT is still …

Indocyanine green-equipped upconversion nanoparticles/CeO2 trigger mutually reinforced dual photodynamic therapy

K Lv, L Yao, X Fu, X Gao, H Wang, Y Zhou, R Zhang… - Nano Today, 2023 - Elsevier
Although photodynamic-based tumor therapy has attracted considerable attention, the
antitumor effect is limited due to the low reactive oxygen species (ROS) generation of …

Combining PD-L1 blockade with immunogenic cell death induced by AIE photosensitizer to improve antitumor immunity

J Li, J Dai, Z Zhuang, Z Meng, JJ Hu, X Lou, F Xia… - Biomaterials, 2022 - Elsevier
Immunogenic cell death (ICD) is considered an effective death mode to trigger immune
response. However, the currently available efficient ICD inducers are quite limited …

Chitosan biguanide induced mitochondrial inhibition to amplify the efficacy of oxygen-sensitive tumor therapies

Z Zhou, C Zheng, Y Liu, W Luo, H Deng, J Shen - Carbohydrate Polymers, 2022 - Elsevier
At present, the tumor's poor oxygen perfusion and limited tumor drug permeation are the
major bottlenecks that limit the therapeutic effectiveness of the oxygen-sensitive antitumor …