Improved personalized adjustment of primary therapy to the perceived risk of relapse by
using new prognostic markers for treatment stratification may be beneficial to patients with …

Clinical management and risk stratification of B-lymphoblastic leukemia/lymphoma (B-
ALL/LBL) depend largely on identification of chromosomal abnormalities obtained using …

The occurrence of IKZF1 deletions increases the risk of relapse in patients with B-cell
precursor acute lymphoblastic leukemia (BCPALL)[1, 2]. Therefore, the development of …

Background Head and neck squamous cell carcinoma (HNSCC) is a leading cancer with
high morbidity and mortality worldwide. The aim is to identify genes with clinical significance …

Copy number variations (CNVs) are widespread in both pediatric and adult cases of B-cell
acute lymphoblastic leukemia (B-ALL); however, their clinical significance remains unclear …

Introduction Secondary genetic alterations, which contribute to the dysregulation of cell cycle
progression and lymphoid specialization, are frequently observed in B-cell precursor acute …

IKZF1 deletions are associated with an increased risk of relapse in B-cell precursor acute
lymphoblastic leukemia (B-ALL), and their accurate detection has great clinical impact. Here …

The IKZF1 gene encodes the transcription factor IKAROS, a master regulator of lymphocyte
differentiation. IKZF1 is commonly deleted in acute lymphoblastic leukaemia (ALL) …

Monosomy 7 is generally considered as an acquired cytogenetic abnormality within
hematopoietic cells, and indicates an especially high risk of progression to bone marrow …

Objetivo: Analisar a evolução clínica e hospitalizações não programadas de crianças com
Leucemia Linfoide Aguda (LLA) de acordo com a classificação pela doença residual …