Ageing is inherent to all human beings, yet why we age remains a hotly contested topic.
Most mechanistic explanations of ageing posit that ageing is caused by the accumulation of …

The textbooks and literature of plant biology indicate that plant cells are totipotent, and that
regeneration occurs via dedifferentiation, by which the cell and its descendents recapitulate …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Most but not all phyla include examples of species that are able to regenerate large sections
of the body plan. The mechanisms underlying regeneration on this scale are currently being …

Decapitated Hydra regenerate their heads via morphallaxis, ie, without significant
contributions made by cell proliferation or interstitial stem cells. Indeed, Hydra depleted of …

The germline of multicellular animals is segregated from somatic tissues, which is an
essential developmental process for the next generation. Although certain ecdysozoans and …

The basis for Hydra's enormous regeneration capacity is the “stem cellness” of its epithelium
which continuously undergoes self-renewing mitotic divisions and also has the option to …

Regeneration of complex structures after injury requires dramatic changes in cellular
behavior. Regenerating tissues initiate a program that includes diverse processes such as …

Understanding the molecular basis of wound healing and regeneration in vertebrates is one
of the main challenges in biology and medicine. This understanding will lead to medical …

Visceral regeneration in sea cucumbers has been studied since early last century; however,
it is only within the last 15 years that real progress has been made in understanding the …