Parkinson's disease is a progressive neurodegenerative condition associated with the
deposition of aggregated α-synuclein. Insights into the pathogenesis of Parkinson's disease …

An accumulating body of evidence suggests that the bacterium Akkermansia muciniphila
exhibits positive systemic effects on host health, mainly by improving immunological and …

The discovery of glucocerebrosidase (GBA1) mutations as the greatest numerical genetic
risk factor for the development of Parkinson disease (PD) resulted in a paradigm shift within …

Cardiac sympathetic denervation, as documented on 123I-metaiodobenzylguanidine (MIBG)
myocardial scintigraphy, is relatively sensitive and specific for distinguishing Parkinson's …

The development of dementia is a devastating aspect of Parkinson's disease (PD), affecting
nearly half of patients within 10 years post-diagnosis. For effective therapies to prevent and …

GBA gene variants were the first genetic risk factor for Parkinson's disease. GBA encodes
the lysosomal enzyme glucocerebrosidase (GBA), which is involved in sphingolipid …

Abstract α-Synuclein misfolds into pathological forms that lead to various neurodegenerative
diseases known collectively as α-synucleinopathies. In this Review, we provide a …

Peripheral inflammatory immune responses are thought to play a major role in the
pathogenesis of Parkinson's disease (PD). The neutrophil-to-lymphocyte ratio (NLR), a …

Parkinson's disease (PD) is the second most common neurodegenerative disease. The
development of PD is closely linked to genetic and environmental factors, with GBA1 …

α-Synucleinopathies comprise a group of neurodegenerative diseases characterized by
altered accumulation of a protein called α-synuclein inside neurons and glial cells. This …