Life exists in three dimensions, but until the turn of the century most electron microscopy
methods provided only 2D image data. Recently, electron microscopy techniques capable of …

Microscopy has gone hand in hand with the study of living systems since van Leeuwenhoek
observed living microorganisms and cells in 1674 using his light microscope. A spectrum of …

Groundbreaking advances in volume electron microscopy and specimen preparation are
enabling the 3-dimensional visualisation of specimens with unprecedented detail, and …

Correlative microscopy, the integration of two or more microscopy techniques performed on
the same sample, produces results that emphasize the strengths of each technique while …

Background & Aims SMAD4 frequently is lost from colorectal cancers (CRCs), which is
associated with the development of metastases and a poor prognosis. SMAD4 loss is …

On August 22, 1879, in a lecture to the British Association for the Advancement of Science, 1
Sir William Crookes announced that “radiant matter”(his term for the electrons emerging from …

This review examines new techniques and applications of organic petrography in source-
rock reservoir petroleum systems that have occurred along with development of the global …

Fluorescence microscopy of GFP-tagged proteins is a fundamental tool in cell biology, but
without seeing the structure of the surrounding cellular space, functional information can be …

Cryogenic electron tomography (cryo-ET) combined with subtomogram averaging, allows in
situ visualization and structure determination of macromolecular complexes at …

Cellular complexity is unraveled at nanometer resolution using electron microscopy (EM),
but interpretation of macromolecular functionality is hampered by the difficulty in interpreting …