Loss of functional β-cell mass is the key mechanism leading to the two main forms of
diabetes mellitus—type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) …

The maintenance of glucose homeostasis is fundamental for survival and health. Diabetes
develops when glucose homeostasis fails. Type 2 diabetes (T2D) is characterized by insulin …

Impaired function of pancreatic islet cells is a major cause of metabolic dysregulation and
disease in humans. Despite this, it remains challenging to directly link physiological …

Summary Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-
producing β cells. A comprehensive picture of the changes during T1D development is …

The pancreatic islets are composed of discrete hormone-producing cells that orchestrate
systemic glucose homeostasis. Here we identify subsets of beta cells using a single-cell …

Pancreatic islet cells derived from human pluripotent stem cells hold great promise for
modeling and treating diabetes. Differences between stem-cell-derived and primary islets …

Metabolic diseases including type 2 diabetes are associated with meta-inflammation. β-Cell
failure is a major component of the pathogenesis of type 2 diabetes. It is now well …

Type 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic β cells. To
identify candidate genes contributing to T2D pathophysiology, we studied human pancreatic …

Type 2 diabetes (T2D) is associated with defective insulin secretion and reduced β cell
mass. Available treatments provide a temporary reprieve, but secondary failure rates are …

Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we
assess whether human β cell dysfunction induced by metabolic stress is reversible, evaluate …