Autotaxin in breast cancer: role, epigenetic regulation and clinical implications

A Drosouni, M Panagopoulou, V Aidinis, E Chatzaki - Cancers, 2022 - mdpi.com
Simple Summary Autotaxin (ATX) has been linked with the pathogenesis of several cancers
and especially with breast cancer (BC). BC is one of the most common cancers among …

Cancer biomarkers in liquid biopsy for early detection of breast cancer: a systematic review

G Duque, C Manterola, T Otzen… - Clinical Medicine …, 2022 - journals.sagepub.com
Background: Breast cancer (BC) is the most common neoplasm in women worldwide. Liquid
biopsy (LB) is a non-invasive diagnostic technique that allows the analysis of biomarkers in …

[HTML][HTML] Autotaxin production in the human breast cancer tumor microenvironment mitigates tumor progression in early breast cancers

MGK Benesch, R Wu, X Tang, DN Brindley… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Autotaxin (ATX) is a secreted enzyme that produces extracellular lysophosphatidate in
physiological wound healing. ATX is overexpressed in many cancers to promote growth …

ENPP2 promotes progression and lipid accumulation via AMPK/SREBP1/FAS pathway in chronic lymphocytic leukemia

L Lu, X Hu, Y Han, H Wang, Z Tian, Y Zhang… - Cellular & Molecular …, 2024 - Springer
Background Disorders of lipid metabolism are critical factors in the progression of chronic
lymphocytic leukemia (CLL). However, the characteristics of lipid metabolism and related …

[HTML][HTML] Stage analysis of breast cancer metabolomics: a system biology approach

Z Hosseinpour, MR Tavirani… - Asian Pacific Journal of …, 2023 - ncbi.nlm.nih.gov
Background: Breast cancer (BC) is the most common malignancy in women worldwide.
Altered miRNA profile can disturb the metabolic homeostatic via regulation of gene …

Exploring the potential biological significance of KDELR family genes in lung adenocarcinoma

P Li, P Cui, Q Yue, Z Xu, Z Liu - Scientific Reports, 2024 - nature.com
Abstract The Lys-Asp-Glu-Leu receptor (KDELR) family genes play critical roles in a variety
of biological processes in different tumors. Our study aimed to provide a comprehensive …

The role of autotaxin and LPA signaling in embryonic development, pathophysiology and cancer

C Magkrioti, E Kaffe, V Aidinis - International Journal of Molecular …, 2023 - mdpi.com
Autotaxin (ATX) or Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) is a
secreted enzyme with lysophospholipase D activity, with its primary function being the …

Methylation signatures as biomarkers for non-invasive early detection of breast cancer: A systematic review of the literature

T Gonzalez, Q Nie, LN Chaudhary, D Basel, HV Reddi - Cancer Genetics, 2024 - Elsevier
Background Early detection of breast cancer would help alleviate the burden of treatment for
early-stage breast cancer and help patient prognosis. There is currently no established gene …

Reductive lipid nanoparticles loaded with vinorelbine inhibit chemotherapy-induced invasion of cancer cells by modulating ENPP2

X Zhao, X Guo, M Pang, W Qiu, Z Luo, Q Lin, Y Lu… - Nano Research, 2024 - Springer
Cancer is a predominant culprit behind worldwide death and accounts for up to 10 million
deaths every year. Chemotherapy is the primary therapeutic method employed for cancer in …

[HTML][HTML] Autotaxin and Lysophosphatidate Signaling: Prime Targets for Mitigating Therapy Resistance in Breast Cancer

MGK Benesch, X Tang, DN Brindley… - World Journal of …, 2024 - ncbi.nlm.nih.gov
Overcoming and preventing cancer therapy resistance is the most pressing challenge in
modern breast cancer management. Consequently, most modern breast cancer research is …