Proteases or proteolytic enzymes form one of the largest and more important groups of
enzymes. Proteases selectively catalyze the hydrolysis of peptide bonds and can be divided …

Cycloaddition reactions between ketenes, bearing amino‐, oxy‐, or halo‐groups, and imines
are recognized as being amongst the most important and direct routes to β‐lactams. Alkyl …

The replacement of hydrogen with fluorine in organic molecules can profoundly influence
their chemical and physical properties, leading to a range of compounds with highly …

Serine hydrolases represent one of the largest and most diverse families of enzymes in
higher eukaryotes, comprising numerous proteases, lipases, esterases, and amidases. The …

The development of exceptionally potent inhibitors of fatty acid amide hydrolase (FAAH), the
enzyme responsible for the degradation of oleamide (an endogenous sleep-inducing lipid) …

Abstract α‐Quaternary ketones are accessed through novel enantioselective alkylations of
allyl and propargyl electrophiles by unstabilized prochiral enolate nucleophiles in the …

Benzoannelated heterocycles such as benzodiazepines and indoles can be prepared
efficiently through cyclization on solid supports, although no single approach is currently …

Fluorinated compounds attracted remarkable interest in recent decades. 1 Unique complex
of physicochemical and biological properties provided by incorporation of fluorine or …

Viruses are major pathogenic agents that can cause a variety of serious diseases in
humans, other animals, and plants. Due to their clinical and scientific importance, viruses …

Since the advent of penicillin, the β-lactam antibiotics have been the subject of much
discussion and investigation, within both the scientific and public sectors. The primary …