Background New drugs and new evidence concerning the use of established treatments
have become available since the publication of the first European League Against …

This review summarizes relevant studies concerning uric acid and possible links to
hypertension, renal disease, and cardiovascular disease. Whether uric acid is an …

Uric acid is the product of purine metabolism. It is known that hyperuricemia, defined as high
levels of blood uric acid, is the major etiological factor of gout. A number of epidemiological …

The actual reference range of serum uric acid has been assessed according to its variations
among healthy individuals. ie those without clinical evidence of gout. By this approach …

Uric acid is the end product of purine metabolism. Its immediate precursor, xanthine, is
converted to uric acid by an enzymatic reaction involving xanthine oxidoreductase. Uric acid …

The definition of hyperuricemia (HU) varies widely in different studies, which makes the
epidemiological reports somewhat inconsistent. HU remains the culprit of the pathogenesis …

Uric acid (urate), an organic compound comprised of carbon, nitrogen, oxygen and
hydrogen, is the final oxidation product of purine catabolism in humans, higher primates and …

Objectives In patients with gout, maintaining too low serum uric acid (SUA) level with urate-
lowering therapy is a concern because uric acid is thought to be neuroprotective. However …

Background: Cerebral small vessel disease (SVD) is a common cause of stroke, mild
cognitive impairment, dementia and physical impairments. Differences in SVD incidence or …

The loss of cognitive function in Alzheimer's disease is pathologically linked with
neurofibrillary tangles, amyloid deposition, and loss of neuronal communication. Cerebral …