New valproate regulations, informed choice and seizure risk

H Angus-Leppan, R Arkell, L Watkins, D Heaney… - Journal of …, 2024 - Springer
Valproate is the most effective medication for generalised epilepsies, and several specific
epilepsy syndromes. For some people, it will be the only medication to establish seizure …

The physiology of male reproduction: Impact of drugs and their abuse on male fertility

AF Ajayi, RE Akhigbe - Andrologia, 2020 - Wiley Online Library
Male factor accounts for about 30–50% of infertility. A common cause of male infertility is
drug abuse; either illicit or prolonged use of prescribed drugs. This study provides a review …

Reproductive health in patients with epilepsy

S Markoula, E Siarava, A Keramida… - Epilepsy & Behavior, 2020 - Elsevier
The aim of the present study was to review existing knowledge on the impact of epilepsy in
reproductive health of both sexes. Extensive searches of relevant documentation published …

Paternal exposure to antiseizure medications and offspring outcomes: a systematic review

E Honybun, G Rayner, CB Malpas… - Journal of Neurology …, 2025 - jnnp.bmj.com
Background Concerns have recently been raised about risks to the fetus resulting from
paternal exposure to antiseizure medications (ASMs). To address these concerns, we …

Research progress on the effect of epilepsy and antiseizure medications on PCOS through HPO axis

S Li, L Zhang, N Wei, Z Tai, C Yu, Z Xu - Frontiers in endocrinology, 2021 - frontiersin.org
Epilepsy is a common chronic neurological disease that manifests as recurrent seizures.
The incidence and prevalence of epilepsy in women are slightly lower than those in men …

Caring for transgender patients with epilepsy

EL Johnson, PW Kaplan - Epilepsia, 2017 - Wiley Online Library
Objective Approximately 25 million individuals older than age 15 identify as transgender,
representing about 0.3–0.9% of the world's population. The aim of this paper is to identify …

Specific patient features affect antiepileptic drug therapy decisions: focus on gender, age, and psychiatric comorbidities

LR Pisani, M Nikanorova, CJ Landmark… - Current …, 2017 - ingentaconnect.com
Background: Patient features, apart from the type of seizures/epilepsy, affect markedly
antiepileptic drug (AED) choice and dosage. The present review focuses on gender, age …

The adverse effects of psychotropic drugs as an endocrine disrupting chemicals on the hypothalamic-pituitary regulation in male

S Ilgin - Life sciences, 2020 - Elsevier
Adverse effects of drugs on male reproductive system can be categorized as pre-testicular,
testicular, and post-testicular. Pre-testicular adverse effects disrupt the hypothalamic …

Preconceptional paternal antiepileptic drugs use and risk of congenital anomalies in offspring: a nationwide cohort study

F Yang, W Yuan, H Liang, X Song, Y Yu… - European journal of …, 2019 - Springer
Recent studies have shown that certain pharmacological agents used by fathers before
conception may increase the risk of adverse neonatal outcomes in offspring. However, little …

The genetic association of polycystic ovary syndrome and the risk of endometrial cancer: a Mendelian randomization study

H Chen, Y Zhang, S Li, Y Tao, R Gao, W Xu… - Frontiers in …, 2021 - frontiersin.org
The association between polycystic ovary syndrome (PCOS) and endometrial cancer
remains unclear. We aimed to investigate the causal association between genetically …