Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …

The majority of human energy metabolism occurs in skeletal muscle mitochondria
emphasizing the importance of understanding the regulation of myocellular mitochondrial …

Skeletal muscle fitness and plasticity is an important determinant of human health and
disease. Mitochondria are essential for maintaining skeletal muscle energy homeostasis by …

The risk associated with multiple cancers, cardiovascular disease, diabetes, and all-cause
mortality is decreased in individuals who meet the current recommendations for physical …

The transcriptional co-activator peroxisome proliferator-activated receptor gamma co-
activator-1 alpha (PGC-1α) is proposed to coordinate skeletal muscle mitochondrial …

Anyone who has ever spent much time in a gym or at sports practice will tell you that the rate
at which a given individual within a group “gets in shape” or acquires new skills in response …

We provide an overview of groundbreaking studies that laid the foundation for our current
understanding of exercise-induced mitochondrial biogenesis and its contribution to human …

PGC1α is a pleiotropic co-factor that affects angiogenesis, mitochondrial biogenesis, and
oxidative muscle remodeling via its association with multiple transcription factors, including …

Endurance exercise has been shown to be a positive regulator of skeletal muscle metabolic
function. Changes in mitochondrial dynamics (fusion and fission) have been shown to …