Discovered more than 30 years ago, the angiotensin AT2 receptor (AT2R) has evolved from
a binding site with unknown function to a firmly established major effector within the …

Since the first identification of renin by Tigerstedt and Bergmann in 1898, the renin-
angiotensin system (RAS) has been extensively studied. The current view of the system is …

The cardiovascular and other actions of angiotensin II (Ang II) are mediated by AT1 and AT2
receptors, which are seven transmembrane glycoproteins with 30% sequence similarity …

A growing body of evidence supports the notion that angiotensin II (Ang II), the central
product of the renin-angiotensin system, may play a central role not only in the etiology of …

Objective To investigate whether angiotensin receptor blockers protect against Alzheimer's
disease and dementia or reduce the progression of both diseases. Design Prospective …

The renin-angiotensin system is a major regulatory system of cardiovascular and renal
function. Basic research has revealed exciting new aspects, which could lead to novel or …

Blockade of the renin-angiotensin system began as a way of studying the pathogenesis of
cardiovascular disease with specific pharmacological probes. Oral activity, achieved by …

A direct, continuous, and independent relation between blood pressure and the incidence of
various cardiovascular events, such as stroke and myocardial infarction, is now well …

MicroRNAs are short noncoding RNAs that function as negative regulators of gene
expression. Posttranscriptional regulation by miRNAs is important for many aspects of …

Angiotensin II (Ang II), the biologically active component of renin-angiotensin system (RAS),
acts through two receptor subtypes, the AT1 and the AT2 receptor. All classic physiological …