Mechanisms of metabolic reprogramming in cancer cells supporting enhanced growth and proliferation

C Schiliro, BL Firestein - Cells, 2021 - mdpi.com
Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …

Insulin-like growth factor 1 (IGF-1) signaling in glucose metabolism in colorectal cancer

A Kasprzak - International journal of molecular sciences, 2021 - mdpi.com
Colorectal cancer (CRC) is one of the most common aggressive carcinoma types worldwide,
characterized by unfavorable curative effect and poor prognosis. Epidemiological data re …

Ketone bodies in neurological diseases: focus on neuroprotection and underlying mechanisms

H Yang, W Shan, F Zhu, J Wu, Q Wang - Frontiers in neurology, 2019 - frontiersin.org
There is growing evidence that ketone bodies, which are derived from fatty acid oxidation
and usually produced in fasting state or on high-fat diets have broad neuroprotective effects …

Targeting the Warburg effect for cancer treatment: Ketogenic diets for management of glioma

A Poff, AP Koutnik, KM Egan, S Sahebjam… - Seminars in Cancer …, 2019 - Elsevier
Gliomas are a highly heterogeneous tumor, refractory to treatment and the most frequently
diagnosed primary brain tumor. Although the current WHO grading system (2016) …

The evolution of ketosis: potential impact on clinical conditions

LN Dilliraj, G Schiuma, D Lara, G Strazzabosco… - Nutrients, 2022 - mdpi.com
Ketone bodies are small compounds derived from fatty acids that behave as an alternative
mitochondrial energy source when insulin levels are low, such as during fasting or …

Mitochondrial substrate-level phosphorylation as energy source for glioblastoma: review and hypothesis

C Chinopoulos, TN Seyfried - ASN neuro, 2018 - journals.sagepub.com
Glioblastoma multiforme (GBM) is the most common and malignant of the primary adult brain
cancers. Ultrastructural and biochemical evidence shows that GBM cells exhibit …

Ketogenic diet and multiple health outcomes: an umbrella review of meta-analysis

S Chen, X Su, Y Feng, R Li, M Liao, L Fan, J Liu… - Nutrients, 2023 - mdpi.com
Numerous studies have examined the effects of ketogenic diets (KD) on health-related
outcomes through meta-analyses. However, the presence of biases may compromise the …

Nutritional impact on metabolic homeostasis and brain health

L Carneiro, L Pellerin - Frontiers in Neuroscience, 2022 - frontiersin.org
Aging in modern societies is often associated with various diseases including metabolic and
neurodegenerative disorders. In recent years, researchers have shown that both …

Current research trends, hotspots, and frontiers of medical nutrition therapy on cancer: a bibliometric analysis

H Xia, L Wang, H Wang - Frontiers in Oncology, 2023 - frontiersin.org
Background There is a high prevalence of malnutrition in cancer patients, which seriously
affects the anti-cancer therapy effect and outcomes, causing a huge disease burden …

Carbohydrate nutrition and the risk of cancer

CA Maino Vieytes, HM Taha, AA Burton-Obanla… - Current nutrition …, 2019 - Springer
Abstract Purpose of Review This review summarizes a selection of epidemiologic research
assessing the associations between carbohydrate intake and cancer incidence and survival …