Autophagy is a conserved process that catabolizes intracellular components to maintain
energy homeostasis and to protect cells against stress. Autophagy has crucial roles during …

The relative insufficiency of insulin secretion and/or insulin action causes diabetes.
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase …

This review focuses on neuropeptides and peptide hormones, the largest and most diverse
class of neuroactive substances, known in Drosophila and other animals to play roles in …

Age is the main risk factor for the prevalent diseases of developed countries: cancer,
cardiovascular disease and neurodegeneration. The ageing process is deleterious for …

During the past century, treatments for the diseases of youth and middle age have helped
raise life expectancy significantly. However, cognitive decline has emerged as one of the …

Hyperinsulinemia is associated with obesity and pancreatic islet hyperplasia, but whether
insulin causes these phenomena or is a compensatory response has remained unsettled for …

Multicellular animals match costly activities, such as growth and reproduction, to the
environment through nutrient-sensing pathways. The insulin/IGF signaling (IIS) pathway …

Alzheimer's disease (AD) is the 3rd most costly disease and the leading cause of dementia.
It can linger for many years, but ultimately is fatal, the 6th leading cause of death …

Human aging is currently defined as a physiological decline of biological functions in the
body with a continual adaptation to internal and external damaging. The endocrine system …

Studies of neuropeptide and peptide hormone signaling are coming of age in Drosophila
due to rapid developments in molecular genetics approaches that overcome the difficulties …