Heme oxygenase (HO)-1 is known to metabolize heme into biliverdin/bilirubin, carbon
monoxide, and ferrous iron, and it has been suggested to demonstrate cytoprotective effects …

Heme oxygenases (HOs) act on heme degradation to produce carbon monoxide (CO), free
iron, ferritin, and biliverdin. Upregulation of cellular HO-1 levels is signature of oxidative …

Mitochondria are well known for their role in ATP production and biosynthesis of
macromolecules. Importantly, increasing experimental evidence points to the roles of …

Heme oxygenase-1 (HO-1) is an inducible intracellular enzyme that is expressed in
response to a variety of stimuli to degrade heme, which generates the biologically active …

Abstract Heme oxygenase-1 (HO-1) is considered to be the main protein in diseases arising
as a result of oxidative and inflammatory insults. Tremendous research has been carried out …

Follicular thyroid cancer (FTC) is a highly aggressive type of endocrine malignancy. It is
necessary to investigate the mechanisms of tumorigenesis and therapeutic pathways in …

Although the pathological significance of tumor-associated macrophage (TAM)
heterogeneity is still poorly understood, TAM reprogramming is viewed as a promising …

Heme oxygenase 1 (HO-1) up-regulation is recognized as a pivotal mechanism of cell
adaptation to stress. Under control of different transcription factors but with a prominent role …

Heme, an iron-containing porphyrin, is of vital importance for cells due to its involvement in
several biological processes, including oxygen transport, energy production and drug …

Cancer cells undergo considerable metabolic changes to foster uncontrolled proliferation in
a hostile environment characterized by nutrient deprivation, poor vascularization and …