Although the physicochemical properties of antimicrobial peptides (AMPs) and anticancer
peptides (ACPs) are very similar, it remains unclear which specific parameter (s) of ACPs …

A functional unfolded protein response (UPR) is essential for endoplasmic reticulum (ER)-
associated degradation (ERAD) of misfolded secretory proteins, reflecting the fact that some …

Commonly used antimicrobials show poor cellular uptake and often have limited access to
intracellular targets, resulting in low antimicrobial activity against intracellular pathogens. An …

Cell‐penetrating peptides (CPPs) are peptides that cross cell membranes, either alone or
while carrying molecular cargo. Although their interactions with mammalian cells have been …

Cell penetrating peptides (CPP s) can be used as drug delivery systems for different
therapeutic molecules. In this work two novel CPP s, pep R and pep M, designed from two …

Cellular uptake and intracellular release efficiency of biomacromolecules is low because of
hurdles in the cell membrane that result in limited access to intra-cellular targets with few …

Monomeric hIAPP significantly destabilizes both model and live cell membranes by
increasing membrane fluidity. This interaction with membranes happens via carpet formation …

Background: In recent years, the multi-drug resistance of bacteria and fungi strains has
become a worldwide problem. The incidence of fungal and bacterial infections is …

Naja atra subsp. atra cardiotoxin 1 (CTX-1), produced by Chinese cobra snakes, belonging
to Elapidae family, is included in the three-finger toxin family and exerts high cytotoxicity and …

Salmonellae, gram-negative bacteria, are facultative intracellular pathogens that cause a
number of diseases in animals and humans. The poor penetration ability of antimicrobial …