Metastatic cancer is almost always terminal, and more than 90% of cancer deaths result from
metastatic disease. Combating cancer metastasis and post-therapeutic recurrence …

The cytoskeleton plays an integral role in maintaining the integrity of epithelial cells.
Epithelial cells primarily employ cytokeratin in their cytoskeleton, whereas mesenchymal …

Control of the structure and function of three-dimensional multicellular tissues depends
critically on the spatial and temporal coordination of cellular physical properties, yet the …

Across complex, multi-time and-length scale biological systems, redundancy confers
robustness and resilience, enabling adaptation and increasing survival under dynamic …

The epithelial-mesenchymal transition (EMT) is intrinsically linked to alterations of the
intracellular cytoskeleton and the extracellular matrix. After EMT, cells acquire an elongated …

Enormous amounts of essential intracellular events are crowdedly packed inside picoliter-
sized cellular space. However, the significance of the physical properties of cells remains …

Living cells are a complex soft material with fascinating mechanical properties. A striking
feature is that, regardless of their types or states, cells exhibit a universal power-law …

The cytoskeleton of eukaryotic cells is primarily composed of networks of filamentous
proteins, F-actin, microtubules, and intermediate filaments. Interactions among the …

Intermediate filaments (IFs) are integral components of the cytoskeleton. They provide cells
with tissue-specific mechanical properties and are involved in numerous cellular processes …

Biological cells and tissues are continuously subjected to mechanical stress and strain cues
from their surrounding substrate. How these forces modulate cell and tissue behavior is a …