Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease
In mammals, the insulin receptor (IR) gene has acquired an additional exon, exon 11. This
exon may be skipped in a developmental and tissue-specific manner. The IR, therefore …
exon may be skipped in a developmental and tissue-specific manner. The IR, therefore …
Targeting growth hormone function: strategies and therapeutic applications
M Lu, JU Flanagan, RJ Langley, MP Hay… - Signal transduction and …, 2019 - nature.com
Human growth hormone (GH) is a classical pituitary endocrine hormone that is essential for
normal postnatal growth and has pleiotropic effects across multiple physiological systems …
normal postnatal growth and has pleiotropic effects across multiple physiological systems …
Growth hormone and reproduction: a review of endocrine and autocrine/paracrine interactions
KL Hull, S Harvey - International journal of endocrinology, 2014 - Wiley Online Library
The somatotropic axis, consisting of growth hormone (GH), hepatic insulin‐like growth factor
I (IGF‐I), and assorted releasing factors, regulates growth and body composition …
I (IGF‐I), and assorted releasing factors, regulates growth and body composition …
Growth hormone in fertility and infertility: Mechanisms of action and clinical applications
CW Chang, YW Sung, YW Hsueh, YY Chen… - Frontiers in …, 2022 - frontiersin.org
Secreted by the anterior pituitary gland, growth hormone (GH) is a peptide that plays a
critical role in regulating cell growth, development, and metabolism in multiple targeted …
critical role in regulating cell growth, development, and metabolism in multiple targeted …
Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies
R Steuerman, O Shevah, Z Laron - European journal of …, 2011 - academic.oup.com
Objective To investigate whether congenital IGF1 deficiency confers protection against
development of malignancies, by comparing the prevalence of malignancies in patients with …
development of malignancies, by comparing the prevalence of malignancies in patients with …
Extrapituitary growth hormone
S Harvey - Endocrine, 2010 - Springer
Pituitary somatotrophs secrete growth hormone (GH) into the bloodstream, to act as a
hormone at receptor sites in most, if not all, tissues. These endocrine actions of circulating …
hormone at receptor sites in most, if not all, tissues. These endocrine actions of circulating …
Autocrine/paracrine human growth hormone-stimulated MicroRNA 96-182-183 cluster promotes epithelial-mesenchymal transition and invasion in breast cancer
Human growth hormone (hGH) plays critical roles in pubertal mammary gland growth,
development, and sexual maturation. Accumulated studies have reported that …
development, and sexual maturation. Accumulated studies have reported that …
Role of the GH-IGF1 system in progression of cancer
Emerging evidence links the growth hormone (GH)-insulin-like growth factor-1 (IGF1)
endocrine axis to cancer development. While this putative correlation is of major …
endocrine axis to cancer development. While this putative correlation is of major …
Over‐expression of lipocalin 2 promotes cell migration and invasion through activating ERK signaling to increase SLUG expression in prostate cancer
G Ding, J Fang, S Tong, L Qu, H Jiang, Q Ding… - The Prostate, 2015 - Wiley Online Library
BACKGROUND Metastasis is the primary cause of prostate cancer (PCa) lethality and poses
a huge clinical obstacle. Lipocalin 2 (LCN2), a member of the lipocalin family, is aberrantly …
a huge clinical obstacle. Lipocalin 2 (LCN2), a member of the lipocalin family, is aberrantly …
MGMT expression predicts response to temozolomide in pancreatic neuroendocrine tumors
Temozolomide (TEM) showed encouraging results in well-differentiated pancreatic
neuroendocrine tumors (WDPNETs). Low O 6-methylguanine-DNA methyltransferase …
neuroendocrine tumors (WDPNETs). Low O 6-methylguanine-DNA methyltransferase …