The heterogeneity of Parkinson's disease (PD) has been recognized since its description by
James Parkinson over 200 years ago. The complexity of motor and non-motor PD …

Abstract PLA2G6-associated neurodegeneration (PLAN) represents a continuum of
clinically and genetically heterogeneous neurodegenerative disorders with overlapping …

Neuronal activity causes use-dependent decline in protein function. However, it is unclear
how this is coupled to local quality control mechanisms. We show in Drosophila that the …

Parkinson's disease is a progressive neurological disorder, characterized by prominent
movement dysfunction. The past two decades have seen a rapid expansion of our …

Abstract Genome-Wide Association Studies (GWAS) have elucidated the genetic
components of Parkinson's Disease (PD). However, because the vast majority of GWAS …

Common genetic factors likely contribute to multiple psychiatric diseases including mood
and substance use disorders. Certain stable, heritable traits reflecting temperament, termed …

Several studies have provided evidence that a subset of patients with essential tremor (ET)
develop Parkinson's disease (PD) after several years or decades, resulting in the ET-PD …

The amygdala is a crucial interconnecting structure in the brain that performs several
regulatory functions, yet its genetic architectures and involvement in brain disorders remain …

Objectives To explore the genetics of four Parkinson's disease (PD) subtypes that have been
previously described in two large cohorts of patients with recently diagnosed PD. These …

Blood-based gene expression signatures could potentially be used as biomarkers for PD.
However, it is unclear whether genetically-regulated transcriptomic signatures can provide …