Keratins—types I and II—are the intermediate-filament-forming proteins expressed in
epithelial cells. They are encoded by 54 evolutionarily conserved genes (28 type I, 26 type …

Historically, the term 'keratin'stood for all of the proteins extracted from skin modifications,
such as horns, claws and hooves. Subsequently, it was realized that this keratin is actually a …

Subcellular membraneless assemblies are a reinvigorated area of study in biology, with
spirited scientific discussions on the forces between the low-complexity protein domains …

It took more than 100 years before it was established that the proteins that form intermediate
filaments (IFs) comprise a unified protein family, the members of which are ubiquitous in …

Intermediate filaments are cytoskeletal polymers encoded by a large family of differentially
expressed genes that provide crucial structural support in the cytoplasm and nucleus of …

Keratins are major components of the epithelial cytoskeleton and are believed to play a vital
role for mechanical integrity at the cellular and tissue level. Keratinocytes as the main cell …

Intermediate filaments (IFs) are cytoskeletal polymers whose protein constituents are
encoded by a large family of differentially expressed genes. Owing in part to their properties …

The diversity of epithelial functions is reflected by the expression of distinct keratin pairs that
are responsible to protect epithelial cells against mechanical stress and to act as signaling …

Epithelia are exposed to multiple forms of stress. Keratin intermediate filaments are
abundant in epithelia and form cytoskeletal networks that contribute to cell type–specific …

Keratins make up the largest subgroup of intermediate filament (IF) proteins and form a
dynamic network of 10–12nm filaments, built from type I/type II heterodimers, in the …