▪ Abstract In addition to CD4, the human immunodeficiency virus (HIV) requires a coreceptor
for entry into target cells. The chemokine receptors CXCR4 and CCR5, members of the G …

The chemokine stromal cell-derived factor 1, SDF-1, is an important regulator of leukocyte
and hematopoietic precursor migration and pre-B cell proliferation. The receptor for SDF-1 …

Brain endothelial cells are unique among endothelial cells in that they express apical
junctional complexes, including tight junctions, which quite resemble epithelial tight …

HIV-associated dementia (HAD) is an important complication of the central nervous system
in patients who are infected with HIV-1. Although the incidence of HAD has markedly …

Abstract Human immunodeficiency virus-1 (HIV-1) can induce dementia with alarming
occurrence worldwide. The mechanism remains poorly understood, but discovery in brain of …

Understanding the mechanisms of immune cell migration to multiple sclerosis lesions offers
significant therapeutic potential. This study focused on the chemokines CXCL12 (SDF-1) …

▪ Abstract Successful viral replication requires not only the efficient production and spread of
progeny, but also evasion of host defense mechanisms that limit replication by killing …

CXCR4 and its ligand CXCL12 mediate the homing of progenitor cells in the bone marrow
and their recruitment to sites of injury, as well as affect processes such as cell arrest …

Chemokines were originally described as chemotactic cytokines involved in leukocyte
trafficking. Research over the last decade, however, has shown that chemokine receptors …

ABSTRACT AMD-3100, a bicyclam, is a novel agent that uniquely inhibits the entry of
human immunodeficiency virus type 1 (HIV-1) into CD4+ T cells via selective blockade of the …