The therapeutic algorithm of renal cell carcinoma has been revolutionized by the approval of
immunotherapy agents by regulatory agencies. However, objective and durable responses …

Germline alterations in many genes coding for proteins regulating DNA repair and DNA
damage response (DDR) to DNA double-strand breaks (DDSB) have been recognized as …

Background: Clear cell renal cell carcinoma (ccRCC) is the most common histological
subtype of renal cell carcinoma (RCC). Anoikis plays an essential function in …

Importance Knowledge about the spectrum of diseases associated with hereditary cancer
syndromes may improve disease diagnosis and management for patients and help to …

Immunotherapy has revolutionized the treatment landscape for many cancer types. The
treatment for renal cell carcinoma (RCC) has especially evolved in recent years, from …

DNA damage response and repair (DDR) gene alterations increase tumor-infiltrating
lymphocytes, genomic instability, and tumor mutational burden (TMB). Whether DDR-related …

Background Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous
disease in which molecular stratification is needed to improve clinical outcomes. The …

Background: High-fidelity repair of DNA damage repair (DDR)(either single-strand-[SSBs] or
double-strand breaks [DSBs]) is necessary for maintaining genomic integrity and cell …

The treatment of metastatic renal cell carcinoma has significantly evolved in recent years,
particularly with the advent of novel immune checkpoint inhibitors (ICI). Despite the striking …

Background Cervical cancer is responsible for 10–15% of cancer-related deaths in women
worldwide. In China, it is the most common cancer in the female genital tract. However, the …