Recent progress in broadly neutralizing antibodies to HIV
D Sok, DR Burton - Nature immunology, 2018 - nature.com
In this Review, we highlight some recent developments in the discovery and application of
broadly neutralizing antibodies (bnAbs) to human immunodeficiency virus (HIV); ie …
broadly neutralizing antibodies (bnAbs) to human immunodeficiency virus (HIV); ie …
HIV-1 vaccines based on antibody identification, B cell ontogeny, and epitope structure
PD Kwong, JR Mascola - Immunity, 2018 - cell.com
HIV-1 vaccine development has been stymied by an inability to induce broadly reactive
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …
Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection
Pre-existing immunity to seasonal endemic coronaviruses could have profound
consequences for antibody responses to SARS-CoV-2, induced from natural infection or …
consequences for antibody responses to SARS-CoV-2, induced from natural infection or …
Selection analysis identifies clusters of unusual mutational changes in Omicron lineage BA. 1 that likely impact Spike function
Among the 30 nonsynonymous nucleotide substitutions in the Omicron S-gene are 13 that
have only rarely been seen in other SARS-CoV-2 sequences. These mutations cluster within …
have only rarely been seen in other SARS-CoV-2 sequences. These mutations cluster within …
Antibody responses to viral infections: a structural perspective across three different enveloped viruses
CD Murin, IA Wilson, AB Ward - Nature microbiology, 2019 - nature.com
Antibodies serve as critical barriers to viral infection. Humoral immunity to a virus is achieved
through the dual role of antibodies in communicating the presence of invading pathogens in …
through the dual role of antibodies in communicating the presence of invading pathogens in …
[HTML][HTML] Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors
Broadly neutralizing antibodies (bnAbs) to the HIV envelope (Env) V2-apex region are
important leads for HIV vaccine design. Most V2-apex bnAbs engage Env with an …
important leads for HIV vaccine design. Most V2-apex bnAbs engage Env with an …
Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice
Eliciting broadly neutralizing antibodies (bnAbs) is the core of HIV vaccine design. bnAbs
specific to the V2-apex region of the HIV envelope acquire breadth and potency with modest …
specific to the V2-apex region of the HIV envelope acquire breadth and potency with modest …
Development of broadly neutralizing antibodies in HIV-1 infected elite neutralizers
Broadly neutralizing antibodies (bNAbs), able to prevent viral entry by diverse global
viruses, are a major focus of HIV vaccine design, with data from animal studies confirming …
viruses, are a major focus of HIV vaccine design, with data from animal studies confirming …
Analysis of B cell receptor repertoires reveals key signatures of the systemic B cell response after SARS-CoV-2 infection
Y Zhang, Q Yan, K Luo, P He, R Hou, X Zhao… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT A comprehensive study of the B cell response against SARS-CoV-2 could be
significant for understanding the immune response and developing therapeutical antibodies …
significant for understanding the immune response and developing therapeutical antibodies …
Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naïve human B cells
JH Lee, L Toy, JT Kos, Y Safonova, WR Schief… - NPJ vaccines, 2021 - nature.com
A successful HIV vaccine eliciting broadly neutralizing antibodies (bnAbs) must overcome
the hurdle of being able to activate naive precursor B cells encoding features within their …
the hurdle of being able to activate naive precursor B cells encoding features within their …