[HTML][HTML] LDHA as a regulator of T cell fate and its mechanisms in disease
M Dai, L Wang, J Yang, J Chen, X Dou, R Chen… - Biomedicine & …, 2023 - Elsevier
T cells are the main force of anti-infection and antitumor and are also involved in
autoimmune diseases. During the development of these diseases, T cells need to rapidly …
autoimmune diseases. During the development of these diseases, T cells need to rapidly …
[HTML][HTML] The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function
M Wenes, A Jaccard, T Wyss, N Maldonado-Pérez… - Cell Metabolism, 2022 - cell.com
Glycolysis, including both lactate fermentation and pyruvate oxidation, orchestrates CD8+ T
cell differentiation. However, how mitochondrial pyruvate metabolism and uptake controlled …
cell differentiation. However, how mitochondrial pyruvate metabolism and uptake controlled …
Optimizing the clinical impact of CAR-T cell therapy in B-cell acute lymphoblastic leukemia: looking back while moving forward
P Safarzadeh Kozani, P Safarzadeh Kozani… - Frontiers in …, 2021 - frontiersin.org
Chimeric antigen receptor T-cell (CAR-T) therapy has been successful in creating
extraordinary clinical outcomes in the treatment of hematologic malignancies including …
extraordinary clinical outcomes in the treatment of hematologic malignancies including …
Mutant IDH inhibits IFNγ–TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma
Abstract Isocitrate dehydrogenase 1 mutations (mIDH1) are common in
cholangiocarcinoma.(R)-2-hydroxyglutarate generated by the mIDH1 enzyme inhibits …
cholangiocarcinoma.(R)-2-hydroxyglutarate generated by the mIDH1 enzyme inhibits …
Glutarate regulates T cell metabolism and anti-tumour immunity
T cell function and fate can be influenced by several metabolites: in some cases, acting
through enzymatic inhibition of α-ketoglutarate-dependent dioxygenases, in others, through …
through enzymatic inhibition of α-ketoglutarate-dependent dioxygenases, in others, through …
[HTML][HTML] Epigenetic strategies to boost CAR T cell therapy
Chimeric antigen receptor (CAR) T cell therapy has led to a paradigm shift in cancer
immunotherapy, but still several obstacles limit CAR T cell efficacy in cancers. Advances in …
immunotherapy, but still several obstacles limit CAR T cell efficacy in cancers. Advances in …
Metabolic and epigenetic orchestration of (CAR) T cell fate and function
Longevity, functionality, and metabolic fitness are key determinants of chimeric antigen
receptor (CAR) T cell efficacy. Activated T cells follow an ordered differentiation program …
receptor (CAR) T cell efficacy. Activated T cells follow an ordered differentiation program …
Oxygen regulation of TET enzymes
Hypoxia has a significant impact on many physiological and pathological processes. Over
the recent years, its role in modulation of epigenetic remodelling has also become clearer. In …
the recent years, its role in modulation of epigenetic remodelling has also become clearer. In …
Cell metabolism-based optimization strategy of CAR-T cell function in cancer therapy
W Li, X Pan, L Chen, H Cui, S Mo, Y Pan… - Frontiers in …, 2023 - frontiersin.org
Adoptive cell therapy (ACT) using chimeric antigen receptor (CAR)-modified T cells has
revolutionized the field of immune-oncology, showing remarkable efficacy against …
revolutionized the field of immune-oncology, showing remarkable efficacy against …
[HTML][HTML] 2-hydroxyglutarate rides the cancer-immunity cycle
Highlights•Cancer cell-derived D-and L-2HG regulate antitumor immunity.•Both 2HG
enantiomers physiologically accumulate in immune cells.•D-2HG and L-2HG should not be …
enantiomers physiologically accumulate in immune cells.•D-2HG and L-2HG should not be …