[HTML][HTML] Antioxidants and vasodilators for the treatment of noise-induced hearing loss: are they really effective?

JC Alvarado, V Fuentes-Santamaría… - Frontiers in cellular …, 2020 - frontiersin.org
We live in a world continuously immersed in noise, an environmental, recreational and
occupational factor present in almost every daily human activity. Exposure to high-level …

[HTML][HTML] Development of the inner ear and regeneration of hair cells after hearing impairment

X Bing, C Liu, X Cao, C Li, X Gao, F Zhu, X Wu… - Fundamental …, 2023 - Elsevier
Hearing loss, as a sensory disorder, is the most common occurrence among humans, which
has received increasing attention from society. It is mainly caused by the damage of inner …

The protective effects of systemic dexamethasone on sensory epithelial damage and hearing loss in targeted Cx26-null mice

K Xu, S Chen, L Xie, Y Qiu, X Liu, X Bai, Y Jin… - Cell Death & …, 2022 - nature.com
Mutations in the GJB2 gene (encoding Connexin26 (Cx26)) are the most common cause of
hereditary deafness, accounting for about a quarter of all cases. Sensory epithelial damage …

Oral antioxidant vitamins and magnesium limit noise-induced hearing loss by promoting sensory hair cell survival: role of antioxidant enzymes and apoptosis genes

JC Alvarado, V Fuentes-Santamaría, P Melgar-Rojas… - Antioxidants, 2020 - mdpi.com
Noise induces oxidative stress in the cochlea followed by sensory cell death and hearing
loss. The proof of principle that injections of antioxidant vitamins and Mg2+ prevent noise …

Recent advancements in gene and stem cell‐based treatment modalities: Potential implications in noise‐induced hearing loss

AA Eshraghi, HD Jung, R Mittal - The Anatomical Record, 2020 - Wiley Online Library
Noise‐induced hearing loss (NIHL) poses a significant burden on not only the economics of
health care but also the quality of life of an individual, as we approach an unprecedented …

[HTML][HTML] Pathogenesis and New Pharmacological Approaches to Noise-Induced Hearing Loss: A Systematic Review

FJ Santaolalla Sanchez, JD Gutierrez Posso… - Antioxidants, 2024 - mdpi.com
Noise-induced hearing loss (NIHL) is responsible for significant adverse effects on
cognition, quality of life and work, social relationships, motor skills, and other psychological …

Pharmacological prevention of noise-induced hearing loss: a systematic review

A Gupta, S Koochakzadeh, SA Nguyen… - Otology & …, 2021 - journals.lww.com
Pharmacological Prevention of Noise-induced Hearing Loss: A... : Otology & Neurotology
Pharmacological Prevention of Noise-induced Hearing Loss: A Systematic Review : Otology & …

Viral‐Mediated Connexin 26 Expression Combined with Dexamethasone Rescues Hearing in a Conditional Gjb2 Null Mice Model

X Wang, L Zhang, S Chen, L Xie, Y Qiu… - Advanced …, 2024 - Wiley Online Library
Abstract GJB2 encodes connexin 26 (Cx26), the most commonly mutated gene causing
hereditary non‐syndromic hearing loss. Cx26 is mainly expressed in supporting cells (SCs) …

The histone deacetylase inhibitor sodium butyrate protects against noise-induced hearing loss in Guinea pigs

DH Yang, J Xie, K Liu, Z Peng, JY Guo, SK Yu… - Neuroscience …, 2017 - Elsevier
Noise-induced hearing loss (NIHL) severely impacts the quality of life of affected individuals.
Oxidative stress resulting from noise exposure is a significant cause of NIHL. Although …

Effect of N-acetyl-cysteine in prevention of noise-induced hearing loss: a systematic review and meta-analysis of randomized controlled trials

PH Chang, CW Liu, SH Hung… - Archives of Medical …, 2021 - pmc.ncbi.nlm.nih.gov
Introduction Noise-induced hearing loss is one of the most prevalent causes of hearing
impairment and occupational diseases. Although multiple factors lead to noise-induced …