Peptide-based coacervates as biomimetic protocells

M Abbas, WP Lipiński, J Wang, E Spruijt - Chemical Society Reviews, 2021 - pubs.rsc.org
Coacervates are condensed liquid-like droplets formed by liquid–liquid phase separation of
molecules through multiple weak associative interactions. In recent years it has emerged …

Recent progress in the science of complex coacervation

CE Sing, SL Perry - Soft Matter, 2020 - pubs.rsc.org
Complex coacervation is an associative, liquid–liquid phase separation that can occur in
solutions of oppositely-charged macromolecular species, such as proteins, polymers, and …

50th Anniversary Perspective: A Perspective on Polyelectrolyte Solutions

M Muthukumar - Macromolecules, 2017 - ACS Publications
From the beginning of life with the information-containing polymers until the present era of a
plethora of water-based materials in health care industry and biotechnology, polyelectrolytes …

Polyelectrolyte complex coacervates: Recent developments and new frontiers

AM Rumyantsev, NE Jackson… - Annual Review of …, 2021 - annualreviews.org
Polyelectrolyte complex coacervates represent a wide class of materials with applications
ranging from coatings and adhesives to pharmaceutical technologies. They also underpin …

Phase behavior and salt partitioning in polyelectrolyte complex coacervates

L Li, S Srivastava, M Andreev, AB Marciel… - …, 2018 - ACS Publications
Polyelectrolyte complexes are omnipresent both in nature and in the technological world,
including nucleotide condensates, biological marine adhesives, food stabilizers …

A short peptide synthon for liquid–liquid phase separation

M Abbas, WP Lipiński, KK Nakashima, WTS Huck… - Nature Chemistry, 2021 - nature.com
Liquid–liquid phase separation of disordered proteins has emerged as a ubiquitous route to
membraneless compartments in living cells, and similar coacervates may have played a role …

Underwater contact adhesion and microarchitecture in polyelectrolyte complexes actuated by solvent exchange

Q Zhao, DW Lee, BK Ahn, S Seo, Y Kaufman… - Nature materials, 2016 - nature.com
Polyelectrolyte complexation is critical to the formation and properties of many biological
and polymeric materials, and is typically initiated by aqueous mixing followed by fluid–fluid …

Sequence and entropy-based control of complex coacervates

LW Chang, TK Lytle, M Radhakrishna… - Nature …, 2017 - nature.com
Biomacromolecules rely on the precise placement of monomers to encode information for
structure, function, and physiology. Efforts to emulate this complexity via the synthetic control …

Polyelectrolyte complex coacervation across a broad range of charge densities

AE Neitzel, YN Fang, B Yu, AM Rumyantsev… - …, 2021 - ACS Publications
Polyelectrolyte complex coacervates of homologous (co) polyelectrolytes with a near-ideally
random distribution of a charged and neutral ethylene oxide comonomer were synthesized …

Biomolecular condensates can both accelerate and suppress aggregation of α-synuclein

WP Lipiński, BS Visser, I Robu, MAA Fakhree… - Science …, 2022 - science.org
Biomolecular condensates present in cells can fundamentally affect the aggregation of
amyloidogenic proteins and play a role in the regulation of this process. While liquid-liquid …