In mammals, a central circadian clock, located in the suprachiasmatic nuclei (SCN) of the
hypothalamus, tunes the innate circadian physiological rhythms to the ambient 24 h light …

Melatonin is a ubiquitous molecule present in almost every live being from bacteria to
humans. In vertebrates, besides being produced in peripheral tissues and acting as an …

Importance Cerebral palsy (CP) is the most common childhood physical disability. Early
intervention for children younger than 2 years with or at risk of CP is critical. Now that an …

An expert review of the aetiology, assessment, and treatment of autism spectrum disorder,
and recommendations for diagnosis, management and service provision was coordinated …

Exogenous melatonin has been investigated as treatment for a number of medical and
surgical diseases, demonstrating encouraging results. The aim of this review was to present …

Insomnia is a serious worldwide health threat, affecting nearly one third of the general
population. Melatonin has been reported to improve sleep efficiency and it was found that …

Objective To assess the efficacy and safety of novel pediatric-appropriate, prolonged-
release melatonin minitablets (PedPRM) versus placebo for insomnia in children and …

The purposes of this paper are to provide an overview of the state of the science of sleep in
children with autism spectrum disorder (ASD), present hypotheses for the high prevalence of …

Background/purpose Melatonin, an indoleamine secreted by the pineal gland, plays a key
role in regulating circadian rhythm. It has chronobiotic, antioxidant, anti-inflammatory and …

Objective To examine whether behavioural strategies designed to improve children's sleep
problems could also improve the symptoms, behaviour, daily functioning, and working …