The impact of stroke on global health is profound, with both high mortality and morbidity
rates. This condition can result from cerebral ischemia, intracerebral hemorrhage (ICH), and …

The NLRP3 inflammasome is dysregulated in autoinflammatory disorders caused by
inherited mutations and contributes to the pathogenesis of several chronic inflammatory …

Pyroptosis is a lytic, proinflammatory type of programmed cell death crucial for the immune
response to pathogen infections and internal danger signals. Gasdermin D (GSDMD) acts …

NLRP3 inflammasome activation, essential for cytokine secretion and pyroptosis in
response to diverse stimuli, is closely associated with various diseases. Upon stimulation …

Cysteine palmitoylation or S-palmitoylation catalyzed by the ZDHHC family of
acyltransferases regulates the biological function of numerous mammalian proteins as well …

Aberrant activity of NLRP3 has been shown associations with severe diseases.
Palmitoylation is a kind of protein post-translational modification, which has been shown to …

NLRP3 is an inflammasome seeding pattern recognition receptor activated in response to
multiple danger signals which perturb intracellular homeostasis. Electrostatic interactions …

Upon RNA virus infection, the signaling adaptor MAVS forms functional prion-like
aggregates on the mitochondrial outer membrane, which serve as a central hub that links …

Inflammasomes are multiprotein complexes that play a crucial role in regulating immune
responses by governing the activation of Caspase‐1, the secretion of pro‐inflammatory …

Pyroptosis, also known as inflammatory necrosis, is a form of programmed cell death
characterized by the activation of gasdermin proteins, leading to the formation of pores in the …