Immune evasion is a hallmark of cancer, enabling tumors to survive contact with the host
immune system and evade the cycle of immune recognition and destruction. Here, we …

The overwhelming majority of proliferating somatic human cells are diploid, and this
genomic state is typically maintained across successive cell divisions. However, failures in …

In cancer, oncogenes can untether themselves from chromosomes onto circular,
extrachromosomal DNA (ecDNA) particles. ecDNA are common in many of the most …

Metastasis is a complex process and the leading cause of cancer-related death globally.
Recent studies have demonstrated that genomic sequencing data from paired primary and …

Cancer is a major cause of global mortality, both in affluent countries and increasingly in
developing nations. Many patients with cancer experience reduced life expectancy and …

While there is a great clinical need to understand the biology of metastatic cancer in order to
treat it more effectively, research is hampered by limited sample availability. Research …

Metastatic melanoma is among the most enigmatic advanced cancers to clinically manage
despite immense progress in the way of available therapeutic options and historic …

Small nucleotide variants in non-coding regions of the genome can alter transcriptional
regulation, leading to changes in gene expression which can activate oncogenic gene …

The diversity of structural variants (SVs) in melanoma and how they impact oncogenesis are
incompletely known. We performed harmonized analysis of SVs across melanoma histologic …

Cancer is a major cause of global mortality, both in affluent countries and increasingly in
developing nations. A large number of patients with cancer experience reduced life …