Startle is a fast response to sudden, intense stimuli and probably protects the organism from
injury by a predator or by a blow. The acoustic startle response (ASR) of mammals is …

The N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis has been proposed to
help understand the etiology and pathophysiology of schizophrenia. This hypothesis was …

Rationale: Sensorimotor gating of the startle reflex can be assessed across species, using
similar stimuli to elicit similar responses. Prepulse inhibition (PPI), a measure of …

Positron emission tomography (PET) imaging with radiotracers that target translocator
protein 18 kDa (TSPO) has become a popular approach to assess putative …

Background: A converging body of evidence implicates the γ-aminobutyric acid (GABA)
neurotransmitter system in the pathogenesis of schizophrenia. Methods: The authors review …

Schizophrenia is a complex mental health disorder with positive, negative and cognitive
symptom domains. Approximately one third of patients are resistant to currently available …

Current research into schizophrenia has remained highly fragmented, much like the clinical
presentation of the disease itself. Differing theories as to the cause and progression of …

Mothers exposed to infections during pregnancy disproportionally birth children who
develop autism and schizophrenia, disorders associated with altered GABAergic function …

Background and rationale Working memory performance is considered to be a core deficit in
schizophrenia and the best predictor of social reintegration and propensity for relapse. This …

Objectives Maternal infection during pregnancy increases risk of severe neuropsychiatric
disorders, including schizophrenia and autism, in the offspring. The most consistent brain …