Prefrontal cortex and depression

DA Pizzagalli, AC Roberts - Neuropsychopharmacology, 2022 - nature.com
The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …

Adult ADHD and comorbid disorders: clinical implications of a dimensional approach

MA Katzman, TS Bilkey, PR Chokka, A Fallu… - BMC psychiatry, 2017 - Springer
Attention-deficit/hyperactivity disorder (ADHD) in the adult population is frequently
associated with comorbid psychiatric diseases that complicate its recognition, diagnosis and …

Toward a better understanding of the mechanisms and pathophysiology of anhedonia: are we ready for translation?

DA Pizzagalli - American Journal of Psychiatry, 2022 - Am Psychiatric Assoc
Anhedonia—the loss of pleasure or lack of reactivity to pleasurable stimuli—remains a
formidable treatment challenge across neuropsychiatric disorders. In major depressive …

Reward processing in depression: a conceptual and meta-analytic review across fMRI and EEG studies

H Keren, G O'Callaghan, P Vidal-Ribas… - American Journal of …, 2018 - Am Psychiatric Assoc
Objective: A role for aberrant reward processing in the pathogenesis of depression has long
been proposed. However, no review has yet examined its role in depression by integrating …

Influences of depression, self-efficacy, and resource management on learning engagement in blended learning during COVID-19

H Heo, CJ Bonk, MY Doo - The Internet and higher education, 2022 - Elsevier
This study examined the structural relationships among self-efficacy, resource management,
and learning engagement during the COVID-19 era based on self-regulation theory. We …

Motivation and cognitive control in depression

I Grahek, A Shenhav, S Musslick, RM Krebs… - Neuroscience & …, 2019 - Elsevier
Depression is linked to deficits in cognitive control and a host of other cognitive impairments
arise as a consequence of these deficits. Despite of their important role in depression, there …

Understanding positive emotion deficits in depression: From emotion preferences to emotion regulation

WM Vanderlind, Y Millgram, AR Baskin-Sommers… - Clinical psychology …, 2020 - Elsevier
Depression is characterized by increased levels of negative affect and decreased levels of
positive affect. Prior research shows that individual differences in emotion regulation play an …

Characterizing anhedonia: A systematic review of neuroimaging across the subtypes of reward processing deficits in depression

A Borsini, ASJ Wallis, P Zunszain, CM Pariante… - Cognitive, Affective, & …, 2020 - Springer
Anhedonia is a key symptom of major depressive disorder (MDD) and comprises
behavioural deficits in three reward processing subtypes: reward liking, reward wanting, and …

Why not try harder? Computational approach to motivation deficits in neuro-psychiatric diseases

M Pessiglione, F Vinckier, S Bouret, J Daunizeau… - Brain, 2018 - academic.oup.com
Motivation deficits, such as apathy, are pervasive in both neurological and psychiatric
diseases. Even when they are not the core symptom, they reduce quality of life, compromise …

The effects of early life stress on reward processing

AM Novick, ML Levandowski, LE Laumann… - Journal of psychiatric …, 2018 - Elsevier
Early life stress (ELS), in the form of childhood maltreatment, abuse, or neglect, increases
the risk for psychiatric sequelae later in life. The neurobiology of response to early stress …